{"id":"W2162429408","doi":"10.1371/journal.pmed.1001713","title":"Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis","year":2014,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Menzies Centre for Australian Studies, King's College London, University of London; University of California, San Diego; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; University College London Hospitals NHS Foundation Trust; Eisai; Bundesministerium für Bildung und Forschung; European Commission; King's College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Synarc; South London and Maudsley NHS Foundation Trust; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Alzheimer's Society; Wellcome Trust; University of Southern California; Psychiatry Research Trust; Medpace; Novartis Pharmaceuticals Corporation; Alfried Krupp von Bohlen und Halbach-Stiftung; Cardiff University; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health; European Molecular Biology Organization; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics","keywords":"Mendelian randomization; Cholesterol; Triglyceride; Disease; Genetic predisposition; Medicine; Alzheimer's disease; Internal medicine; Genetics; Bioinformatics; Physiology; Biology; Genotype; Genetic variants; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003001294,0.0002085756,0.0006872564,0.0004818227,0.00008159251,0.00001138268,0.00004835215,0.00006045451,0.0001136541],"category_scores_gemma":[0.0004849156,0.0001492341,0.000081673,0.0005008373,0.0001615877,0.00006872401,0.0000371837,0.0001088692,0.00000429858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504412,"about_ca_system_score_gemma":0.00005095873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002965462,"about_ca_topic_score_gemma":0.00001800557,"domain_scores_codex":[0.9981526,0.0002554455,0.0003957482,0.000392618,0.0005558995,0.0002477389],"domain_scores_gemma":[0.9982542,0.0001846662,0.0001479913,0.0003479866,0.0001764367,0.0008886601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004743037,0.0006982283,0.942111,0.0002296283,0.04356069,0.00004875421,0.0003286953,0.000030782,0.003196867,0.000007252551,0.0001614903,0.004883643],"study_design_scores_gemma":[0.02089671,0.001039219,0.9014816,0.0002538904,0.06850434,0.000009875295,0.00002633793,0.005754253,0.001837363,0.00005486269,0.00001961381,0.0001219288],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916668,0.003977155,0.0008113726,0.002222807,0.00001328222,0.00109652,0.0001023643,0.0000360012,0.00007368697],"genre_scores_gemma":[0.9978992,0.0004284044,0.000443987,0.0007059487,0.0002354863,0.0001009117,0.0001543698,0.00002386038,0.000007777062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04062933,"threshold_uncertainty_score":0.608559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931303797450905,"score_gpt":0.281304114076037,"score_spread":0.2619910761015279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}