{"id":"W2162429408","doi":"10.1371/journal.pmed.1001713","title":"Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis","year":2014,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Menzies Centre for Australian Studies, King's College London, University of London; University of California, San Diego; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; University College London Hospitals NHS Foundation Trust; Eisai; Bundesministerium für Bildung und Forschung; European Commission; King's College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Synarc; South London and Maudsley NHS Foundation Trust; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Alzheimer's Society; Wellcome Trust; University of Southern California; Psychiatry Research Trust; Medpace; Novartis Pharmaceuticals Corporation; Alfried Krupp von Bohlen und Halbach-Stiftung; Cardiff University; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health; European Molecular Biology Organization; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics","keywords":"Mendelian randomization; Cholesterol; Triglyceride; Disease; Genetic predisposition; Medicine; Alzheimer's disease; Internal medicine; Genetics; Bioinformatics; Physiology; Biology; Genotype; Genetic variants; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04737404,0.002614985,0.005063034,0.003267938,0.0009479622,0.001551077,0.002587696,0.002017428,0.006124302],"category_scores_gemma":[0.04947924,0.001220898,0.01607576,0.003729671,0.001216486,0.001156946,0.001300457,0.001774127,0.0004254492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008089114,"about_ca_system_score_gemma":0.001200599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003694723,"about_ca_topic_score_gemma":0.002355834,"domain_scores_codex":[0.9460046,0.0397343,0.002924351,0.007985919,0.002425693,0.0009251388],"domain_scores_gemma":[0.9589428,0.03134463,0.003109227,0.004952259,0.001153871,0.000497135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.06017018,0.00035936,0.3807367,0.003953402,0.492024,0.00375056,0.0004635192,0.01126547,0.00659454,0.00668514,0.004485275,0.02951188],"study_design_scores_gemma":[0.03190121,0.007777289,0.1973839,0.0009216382,0.5664708,0.005509236,0.0003685232,0.1555021,0.002811686,0.0225263,0.008373683,0.0004535793],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8078529,0.02939287,0.1499015,0.001821547,0.001045022,0.002301065,0.004180467,0.001202268,0.002302472],"genre_scores_gemma":[0.9693242,0.001398611,0.02601041,0.0003048538,0.0001376936,0.001321658,0.0008814873,0.00008193848,0.0005390326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04737404,"threshold_uncertainty_score":0.2505409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931303797450905,"score_gpt":0.281304114076037,"score_spread":0.2619910761015279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}