{"id":"W2162432199","doi":"10.1371/journal.ppat.1003981","title":"Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Mental Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"IRF3; Interferon; Inositol; Biology; Interferon regulatory factors; Inositol phosphate; Cell biology; Signal transduction; Transcription factor; Biochemistry; Receptor; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006208529,0.0002748388,0.0004198478,0.0003004313,0.0002629235,0.00006085683,0.0004399039,0.0002844001,0.0004241226],"category_scores_gemma":[0.0004499972,0.0002639548,0.0001298347,0.0001336968,0.0001887827,0.0001725239,0.0001500785,0.0002671589,0.0004536692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006429019,"about_ca_system_score_gemma":0.00005155655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009188148,"about_ca_topic_score_gemma":0.0001509037,"domain_scores_codex":[0.9977022,0.0007648856,0.0004739289,0.0004609435,0.00004993566,0.0005480724],"domain_scores_gemma":[0.998871,0.0003157685,0.0001310552,0.0004987417,0.0001426029,0.00004079399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006309582,0.0003178373,0.002454319,0.0000226641,0.0001058239,0.000006025316,0.001246082,0.000004704281,0.9885723,0.0001814002,0.0003681379,0.0004111087],"study_design_scores_gemma":[0.001602756,0.002178995,0.06789068,0.0000760656,0.00006682293,0.00001084103,0.0007346959,0.00003778614,0.918329,0.0002116603,0.008494793,0.0003658796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971474,0.001267298,0.0001319575,0.0001378953,0.0004791488,0.0004575487,0.00007803331,0.0001050843,0.0001956617],"genre_scores_gemma":[0.9957277,0.00002341117,0.00009504828,0.0001962535,0.00006928547,0.00006845899,0.0002546173,0.00005301359,0.003512186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07024329,"threshold_uncertainty_score":0.9999813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431315658905343,"score_gpt":0.2598123050422381,"score_spread":0.2454991484531846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}