{"id":"W2162432199","doi":"10.1371/journal.ppat.1003981","title":"Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institute of Mental Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"IRF3; Interferon; Inositol; Biology; Interferon regulatory factors; Inositol phosphate; Cell biology; Signal transduction; Transcription factor; Biochemistry; Receptor; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153967,0.0004532868,0.0003402602,0.000363974,0.0001532723,0.0003231711,0.0001850497,0.0002717789,0.001361485],"category_scores_gemma":[0.0001120468,0.0001759349,0.0003002566,0.0002666067,0.0001199634,0.00008692624,0.0002067092,0.0003668603,0.0005781154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632278,"about_ca_system_score_gemma":0.0003037259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006640851,"about_ca_topic_score_gemma":0.001365202,"domain_scores_codex":[0.9998982,0.00000999335,0.00000994198,0.00002888499,0.00003757342,0.00001546276],"domain_scores_gemma":[0.9999321,0.00001436549,0.00002365203,0.000007139252,0.00000852165,0.00001436804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001589266,0.00002366709,0.001133371,0.00006290758,0.00002575857,0.0002750422,0.000005974701,0.0001325389,0.9928906,0.0001052355,0.0002449339,0.004941039],"study_design_scores_gemma":[0.00004815201,0.0002058447,0.03813601,0.00001730389,0.0001893704,0.001152696,0.00002173949,0.001822905,0.9508088,0.0002027036,0.007379416,0.00001506063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754133,0.004841492,0.007649472,0.000262168,0.00003669028,0.000081479,0.00657401,0.0007178742,0.004423515],"genre_scores_gemma":[0.9813098,0.002613595,0.005725747,0.0002602208,0.00001409188,0.00005900795,0.00759074,0.00006687242,0.002360023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361485,"threshold_uncertainty_score":0.004554629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431315658905343,"score_gpt":0.2598123050422381,"score_spread":0.2454991484531846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}