{"id":"W2162474938","doi":"10.1042/bj20120938","title":"RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation","year":2012,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Docking (animal); Phosphorylation; MAPK/ERK pathway; Chemistry; Cell biology; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002750756,0.0001798843,0.0001373347,0.00005192824,0.0003080294,0.0001018362,0.0001155596,0.0001755574,0.00006010237],"category_scores_gemma":[0.0007722636,0.0001671435,0.00008648562,0.00008373773,0.00008122907,0.00003798379,0.0001324881,0.0003159292,0.000006832556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004580087,"about_ca_system_score_gemma":0.00003404394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008609408,"about_ca_topic_score_gemma":4.90386e-7,"domain_scores_codex":[0.9988955,0.00006083772,0.0002924303,0.0002200728,0.0001638106,0.0003673549],"domain_scores_gemma":[0.9992127,0.00006320453,0.000238117,0.0001418073,0.0001427551,0.0002013737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005315135,0.0000417033,0.01167419,0.00001037141,0.00005496922,5.837892e-7,0.0002121822,0.000005809472,0.9841777,0.00002597411,0.001621104,0.002122243],"study_design_scores_gemma":[0.0003200331,0.00006576565,0.006697817,0.00008973059,0.00002033105,0.0002558938,0.0003637594,0.00006890584,0.9895139,0.000130451,0.002267013,0.0002064413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958019,0.001385604,0.001585552,0.0001629128,0.0001394293,0.0000985932,0.000003751461,0.00001675673,0.0008054519],"genre_scores_gemma":[0.9903083,0.00007253876,0.007839641,0.0001154349,0.001335551,0.000009841535,0.00003076652,0.00002838701,0.0002594987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00625409,"threshold_uncertainty_score":0.6815912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563230015449468,"score_gpt":0.2729273253542077,"score_spread":0.257295025199713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}