{"id":"W2162478729","doi":"10.1042/bj20140675","title":"Active transporters as enzymes: an energetic framework applied to major facilitator superfamily and ABC importer systems","year":2015,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Major facilitator superfamily; Transporter; Active transport; Biophysics; Chemistry; Membrane transport protein; Biochemistry; ATP-binding cassette transporter; Transport protein; Membrane transport; SUPERFAMILY; Membrane; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004850462,0.001310637,0.001875166,0.002889361,0.00047896,0.001439565,0.001168134,0.001792943,0.002713207],"category_scores_gemma":[0.00054954,0.0003966849,0.0008425508,0.003646193,0.001577538,0.003200671,0.001040412,0.002330805,0.001540607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001317896,"about_ca_system_score_gemma":0.001036995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001197528,"about_ca_topic_score_gemma":0.001134424,"domain_scores_codex":[0.9997308,0.00005712592,0.00003672483,0.00005049938,0.00009742584,0.00002747181],"domain_scores_gemma":[0.9998007,0.000102758,0.00002740183,0.000007877363,0.00004666527,0.00001447656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00009099714,0.00009730333,0.0003367529,0.0272829,0.0001695362,0.0008162133,0.0005364653,0.004183841,0.008043646,0.2190971,0.02664226,0.712703],"study_design_scores_gemma":[0.00001032704,0.00007560052,0.000454337,0.00206581,0.00006568062,0.001339733,0.0001526225,0.0007282732,0.0008090065,0.03912758,0.9551319,0.00003910851],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002797302,0.9940807,0.002223199,0.0005473655,0.000333365,0.000007740101,0.0000179719,0.00001804553,0.002491885],"genre_scores_gemma":[0.002480295,0.9939579,0.001544327,0.0002623932,0.0003979001,0.00001901733,0.00002709592,0.000004570736,0.001306637],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002889361,"threshold_uncertainty_score":0.009562075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03664962301085958,"score_gpt":0.3346597109380444,"score_spread":0.2980100879271849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}