{"id":"W2162478729","doi":"10.1042/bj20140675","title":"Active transporters as enzymes: an energetic framework applied to major facilitator superfamily and ABC importer systems","year":2015,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Major facilitator superfamily; Transporter; Active transport; Biophysics; Chemistry; Membrane transport protein; Biochemistry; ATP-binding cassette transporter; Transport protein; Membrane transport; SUPERFAMILY; Membrane; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000497861,0.0007902552,0.002668362,0.0003039347,0.0001154532,0.00009780703,0.0003410527,0.001054833,0.00007066157],"category_scores_gemma":[0.00004516909,0.0005468265,0.0005358675,0.000295412,0.0001429574,0.00007936594,0.00002302014,0.001466783,0.00004648912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958612,"about_ca_system_score_gemma":0.0008091527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009682312,"about_ca_topic_score_gemma":7.521844e-7,"domain_scores_codex":[0.996402,0.00007471923,0.001195387,0.0007755139,0.0008734447,0.0006789256],"domain_scores_gemma":[0.9968512,0.00007884268,0.00028794,0.0004936476,0.0001831825,0.002105183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003863618,0.001548363,0.00005050442,0.05804594,0.004873296,0.004782689,0.00516426,0.000001778938,0.01437303,0.001953084,0.01097294,0.8943705],"study_design_scores_gemma":[0.001219792,0.0005821806,0.00002483843,0.01789791,0.003483436,0.002305503,0.001312529,9.415239e-7,0.0006619304,0.0002333511,0.9712672,0.001010362],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006933238,0.9895082,0.0007699375,0.00007720467,0.0008409215,0.001288285,0.0002068054,0.00007047445,0.0003049117],"genre_scores_gemma":[0.006432815,0.9882166,0.002019473,0.0002981869,0.001919216,0.0001522304,0.0003475577,0.0001685005,0.0004453889],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9602943,"threshold_uncertainty_score":0.9996983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03664962301085958,"score_gpt":0.3346597109380444,"score_spread":0.2980100879271849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}