{"id":"W2162511271","doi":"10.1111/bph.13204","title":"Quinazoline‐4‐piperidine sulfamides are specific inhibitors of human <scp>NPP</scp>1 and prevent pathological mineralization of valve interstitial cells","year":2015,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; PROTEO; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fonds de recherche du Québec – Nature et technologies; Université Laval; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Pharmacology; Population; Piperidine; Biochemistry; Medicine; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012678,0.0003359349,0.0002147206,0.0001239259,0.00008204879,0.0001110028,0.0002560513,0.0001893582,0.00166386],"category_scores_gemma":[0.0001416127,0.0001051884,0.0001517221,0.00008241484,0.0001938786,0.00009485654,0.00008458368,0.0003287293,0.0002331343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001649262,"about_ca_system_score_gemma":0.0001953542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006736526,"about_ca_topic_score_gemma":0.001500047,"domain_scores_codex":[0.9998858,0.00002798482,0.00001160971,0.00002261034,0.00002752096,0.00002444233],"domain_scores_gemma":[0.9998915,0.00003414277,0.00003432887,0.000008957322,0.00001085746,0.00002013515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000250918,0.00006095709,0.000131847,0.00008479066,0.000007261543,0.00003668014,0.00001068924,0.00009907361,0.9969881,0.00003490327,0.00005289653,0.002241944],"study_design_scores_gemma":[0.0001308795,0.003033487,0.004429189,0.000006656651,0.00002051919,0.0003467484,0.0000112382,0.0006741766,0.9895392,0.00001393478,0.001788524,0.00000535916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919647,0.004846611,0.001609409,0.00007580427,0.0000252589,0.00005878041,0.0002279216,0.00007077577,0.001120819],"genre_scores_gemma":[0.9935448,0.002026282,0.002347053,0.00003903398,0.00001344109,0.00004162261,0.000531089,0.000009715325,0.001447117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166386,"threshold_uncertainty_score":0.00556618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0447033721843987,"score_gpt":0.3275735393365117,"score_spread":0.282870167152113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}