{"id":"W2162540156","doi":"10.1146/annurev.immunol.24.021605.090535","title":"A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION","year":2005,"lang":"en","type":"review","venue":"Annual Review of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":510,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Biology; Regulator; Function (biology); Immune system; Neuroscience; Cytotoxic T cell; CTLA-4; Computational biology; Translation (biology); T cell; Cell biology; Immunology; Genetics; Gene; In vitro; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004504127,0.0005349137,0.003426005,0.0004370581,0.00005745349,0.00000275343,0.0004711704,0.0008383775,0.003070571],"category_scores_gemma":[0.0005165022,0.0004379012,0.001388572,0.0004838952,0.0003984665,0.000143209,0.0001717494,0.0009150695,0.00110667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778144,"about_ca_system_score_gemma":0.0003314947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008793851,"about_ca_topic_score_gemma":0.000001202838,"domain_scores_codex":[0.9963577,0.0009999679,0.00171314,0.0005003872,0.00006875486,0.0003600398],"domain_scores_gemma":[0.9962947,0.0002353931,0.001824984,0.0007808626,0.0008489056,0.000015098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007897374,0.0002070258,1.064748e-7,0.03893402,0.002239406,0.000002161041,0.00009514362,8.881653e-8,0.0006260686,0.005311345,0.0117377,0.9407679],"study_design_scores_gemma":[0.0002912306,0.0006572485,0.000001342138,0.06229278,0.001870406,0.0002200662,0.0001956523,2.701092e-8,0.0004192806,0.00002331519,0.9337434,0.0002852838],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001648542,0.9855267,0.00006511869,0.00008563739,0.00258329,0.0008679627,0.00006439706,0.00004099101,0.01076423],"genre_scores_gemma":[0.0000191149,0.9949366,0.00001458511,0.0002623534,0.0000410607,0.00009376006,0.0004771855,0.00005271447,0.004102555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9404827,"threshold_uncertainty_score":0.9998073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432196002198813,"score_gpt":0.3126701390281694,"score_spread":0.2983481790061813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}