{"id":"W2162540156","doi":"10.1146/annurev.immunol.24.021605.090535","title":"A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION","year":2005,"lang":"en","type":"review","venue":"Annual Review of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":510,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Biology; Regulator; Function (biology); Immune system; Neuroscience; Cytotoxic T cell; CTLA-4; Computational biology; Translation (biology); T cell; Cell biology; Immunology; Genetics; Gene; In vitro; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005257705,0.0008894726,0.0009775651,0.001018196,0.0003098344,0.001177334,0.001352562,0.001632594,0.002882177],"category_scores_gemma":[0.0003046572,0.0002201489,0.0003512706,0.0009453722,0.001136014,0.002074894,0.0007101586,0.002873551,0.003439421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001578412,"about_ca_system_score_gemma":0.001001192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007822165,"about_ca_topic_score_gemma":0.0007283658,"domain_scores_codex":[0.9998748,0.00002767972,0.00001014845,0.00002429466,0.00004013278,0.00002288508],"domain_scores_gemma":[0.9999046,0.00002650284,0.0000120987,0.000006916409,0.0000298264,0.00002002164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002747914,0.0001077532,0.0002643929,0.007513136,0.00007998229,0.001134944,0.0001710396,0.001317493,0.03491499,0.08790517,0.05832614,0.8079903],"study_design_scores_gemma":[0.00001967998,0.0001006674,0.000373112,0.0007136325,0.00002287764,0.001089503,0.00007014961,0.0001788699,0.002215368,0.01549985,0.979703,0.00001320853],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004267889,0.9906533,0.0007660984,0.003323701,0.001149838,0.000003667555,0.00001446654,0.00002031373,0.003641944],"genre_scores_gemma":[0.005440501,0.9861101,0.0007123917,0.002069433,0.001110652,0.00001241157,0.00003178001,0.000003505595,0.004509192],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002882177,"threshold_uncertainty_score":0.0114522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432196002198813,"score_gpt":0.3126701390281694,"score_spread":0.2983481790061813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}