{"id":"W2162550384","doi":"10.1242/jcs.113.3.471","title":"Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II","year":2000,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Myosin; Myosin light-chain kinase; Cytoskeleton; Cell biology; Biology; PAK1; CDC42; RAC1; Actin; Actin cytoskeleton; Staurosporine; Phosphorylation; Protein kinase C; Biochemistry; Cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000519592,0.000216445,0.0001393182,0.0001434336,0.0001321809,0.0002201319,0.0001126893,0.0001641192,0.0009736027],"category_scores_gemma":[0.00008306529,0.0001237035,0.0001947647,0.00009682579,0.0001157378,0.0001086465,0.0001648015,0.0005356871,0.0002583291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894296,"about_ca_system_score_gemma":0.0001330861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003951855,"about_ca_topic_score_gemma":0.0004697476,"domain_scores_codex":[0.9999119,0.000009693302,0.000006152982,0.00001215418,0.00002166536,0.00003833915],"domain_scores_gemma":[0.9999464,0.000006684964,0.00001680394,0.000006110237,0.000006251606,0.00001778666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005496656,0.00001061102,0.00008509476,0.00001264707,0.000002079001,0.00005390938,0.000005652605,0.00001332497,0.9993661,0.00003769541,0.00001892383,0.0003390958],"study_design_scores_gemma":[0.00002539081,0.0002566023,0.01444912,0.000005489913,0.00001190184,0.000450307,0.0000294147,0.001175473,0.9818059,0.00004525034,0.001740935,0.000004234386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973872,0.0005037373,0.000681394,0.00004852669,0.00001280731,0.00000887099,0.0001098032,0.00003042816,0.00121733],"genre_scores_gemma":[0.9964073,0.0005375457,0.0008193346,0.00004932681,0.0000112235,0.00002464294,0.0002659763,0.00000827542,0.001876359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009736027,"threshold_uncertainty_score":0.003257036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006983209224954002,"score_gpt":0.2337112580372845,"score_spread":0.2267280488123305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}