{"id":"W2162566576","doi":"10.1091/mbc.12.11.3631","title":"Signaling through Adenylyl Cyclase Is Essential for Hyphal Growth and Virulence in the Pathogenic Fungus<i>Candida albicans</i>","year":2001,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":345,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Biology; Adenylyl cyclase; Candida albicans; cAMP-dependent pathway; Corpus albicans; ADCY10; Mutant; Fungal protein; Saccharomyces cerevisiae; Microbiology; Cell biology; Signal transduction; Gene; Gs alpha subunit; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008606398,0.0003546902,0.0001437482,0.0001984605,0.0002150201,0.0004272765,0.0001884884,0.000244139,0.0008358458],"category_scores_gemma":[0.0001521916,0.0001271585,0.0002554795,0.00014051,0.0002051911,0.0001729163,0.0002420978,0.0004509217,0.0003947176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004481009,"about_ca_system_score_gemma":0.0003670709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001676847,"about_ca_topic_score_gemma":0.001708344,"domain_scores_codex":[0.9998436,0.00001924511,0.0000135158,0.00003084512,0.00005782865,0.00003500678],"domain_scores_gemma":[0.9998891,0.000017356,0.00002898987,0.00001364347,0.00001762396,0.00003324616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004638816,0.000008803408,0.0002104575,0.00002260785,0.000001478364,0.00005529526,0.000006732938,0.00004034165,0.9985628,0.0001054587,0.00003525658,0.0009044408],"study_design_scores_gemma":[0.00001411219,0.000101086,0.01467531,0.000009667497,0.00001472347,0.0005954129,0.00003870684,0.00146194,0.9802977,0.0001566111,0.002625335,0.000009503086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923718,0.001879768,0.002658565,0.0002332299,0.00002701689,0.00002778771,0.0007907867,0.0002216257,0.001789419],"genre_scores_gemma":[0.9952887,0.0006891441,0.002357947,0.00004115083,0.00001029094,0.00001845018,0.0007445688,0.00002201276,0.0008276431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676847,"threshold_uncertainty_score":0.003334165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033464029799147,"score_gpt":0.27537381160606,"score_spread":0.2650391713080685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}