{"id":"W2162566576","doi":"10.1091/mbc.12.11.3631","title":"Signaling through Adenylyl Cyclase Is Essential for Hyphal Growth and Virulence in the Pathogenic Fungus<i>Candida albicans</i>","year":2001,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":345,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Biology; Adenylyl cyclase; Candida albicans; cAMP-dependent pathway; Corpus albicans; ADCY10; Mutant; Fungal protein; Saccharomyces cerevisiae; Microbiology; Cell biology; Signal transduction; Gene; Gs alpha subunit; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915946,0.0001298238,0.0002420189,0.00002333729,0.00008090249,0.000005882886,0.0002160625,0.0001218458,0.00002685388],"category_scores_gemma":[0.0001017533,0.00007609891,0.0001641474,0.0001436716,0.0003415953,0.00002221533,0.00005525225,0.0001641311,0.000001492621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001244474,"about_ca_system_score_gemma":0.00005521749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009833419,"about_ca_topic_score_gemma":0.00003007205,"domain_scores_codex":[0.9989706,0.000150566,0.0002328846,0.0002886003,0.0001123602,0.0002450057],"domain_scores_gemma":[0.9993671,0.000132305,0.00008760308,0.0003380495,0.00004296302,0.00003196731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003229095,0.0001069556,0.03726541,0.00008269524,0.00002276295,0.0000271009,0.0004208655,0.000001709113,0.9611657,0.0003104549,0.00008685678,0.0001865366],"study_design_scores_gemma":[0.001692258,0.0003441105,0.009972451,0.00006408567,0.00017049,0.00004535261,0.0004054463,0.00006386977,0.9809665,0.005216747,0.0009143089,0.0001443442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899415,0.00269111,0.004603567,0.001605056,0.00006480451,0.0004743738,0.00002907517,0.000006145718,0.0005843785],"genre_scores_gemma":[0.9967236,0.0002524898,0.0005053115,0.002337389,0.00004263923,0.00001832664,0.00001029044,0.00001027,0.00009967853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02729296,"threshold_uncertainty_score":0.3103223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033464029799147,"score_gpt":0.27537381160606,"score_spread":0.2650391713080685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}