{"id":"W2162579298","doi":"10.1158/1535-7163.mct-13-1086","title":"Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Erlotinib; EGFR inhibitors; Epidermal growth factor receptor; Pharmacology; Monensin; Cancer research; Cytotoxicity; Chemistry; Medicine; Internal medicine; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827339,0.0002505864,0.0004631794,0.000298786,0.0001728481,0.0003410579,0.0001790201,0.0002153692,0.000828046],"category_scores_gemma":[0.0001256486,0.0001080817,0.0003209885,0.0002066239,0.0001357604,0.0001468118,0.000265806,0.0004038939,0.000273069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003831749,"about_ca_system_score_gemma":0.0002946856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077091,"about_ca_topic_score_gemma":0.007670533,"domain_scores_codex":[0.9998471,0.00002666542,0.00001258144,0.00002350525,0.00004470577,0.0000454145],"domain_scores_gemma":[0.9999299,0.0000130195,0.00001199217,0.000007528422,0.00001326424,0.00002424073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009190585,0.000175294,0.00121853,0.0001918953,0.00004544354,0.0001663563,0.00002947554,0.0003540055,0.982375,0.00005025956,0.0003986206,0.01407604],"study_design_scores_gemma":[0.0001505431,0.003121828,0.01995742,0.00002524645,0.0001607299,0.001096283,0.00008940064,0.001369692,0.9628518,0.0000451005,0.01110835,0.00002361194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896271,0.006555486,0.0009112533,0.0001833378,0.00005722236,0.00008806668,0.0004990936,0.0000952901,0.001983101],"genre_scores_gemma":[0.9936116,0.002297665,0.001432782,0.0001141014,0.00001460969,0.00003535749,0.0005966916,0.000011403,0.001885779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077091,"threshold_uncertainty_score":0.00278008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03595096515547805,"score_gpt":0.2923542518459029,"score_spread":0.2564032866904248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}