{"id":"W2162579298","doi":"10.1158/1535-7163.mct-13-1086","title":"Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Veterinary medicine and infectious diseases","field":"Veterinary","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Erlotinib; EGFR inhibitors; Epidermal growth factor receptor; Pharmacology; Monensin; Cancer research; Cytotoxicity; Chemistry; Medicine; Internal medicine; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125367,0.0002611069,0.0002795382,0.0001620739,0.0001071005,0.00004322818,0.00007980006,0.0001101785,0.000043032],"category_scores_gemma":[0.00004226662,0.0002334803,0.00004471852,0.0002898617,0.000113225,0.0002044292,0.00003612076,0.0002228945,0.000005212938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641823,"about_ca_system_score_gemma":0.00005738802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002095956,"about_ca_topic_score_gemma":0.00002764407,"domain_scores_codex":[0.9985699,0.0002254603,0.0002804269,0.0003597292,0.0002735336,0.0002909731],"domain_scores_gemma":[0.9993789,0.00009154921,0.0001331865,0.0001916573,0.000108343,0.00009642579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100911,0.0005364383,0.02815416,0.0002846564,0.0001937003,0.000114748,0.001715402,0.0003253418,0.9467722,0.0008686063,0.0001003328,0.01983357],"study_design_scores_gemma":[0.0145626,0.01295452,0.221111,0.002311059,0.0004018979,0.0003046168,0.0007810305,0.01730546,0.7197115,0.0009488065,0.006855344,0.002752093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942794,0.0002713532,0.003745686,0.0007894201,0.000171762,0.0003445031,0.000009482566,0.0000981013,0.0002902675],"genre_scores_gemma":[0.9980534,0.00008178886,0.0001425136,0.001423488,0.0001528675,0.00006127983,0.00002045376,0.0000528988,0.00001128993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2270606,"threshold_uncertainty_score":0.9521049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03595096515547805,"score_gpt":0.2923542518459029,"score_spread":0.2564032866904248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}