{"id":"W2162587246","doi":"10.1093/toxsci/kfm105","title":"Calpain Inhibition but not Reticulum Endoplasmic Stress Preconditioning Protects Rat Kidneys from p-Aminophenol Toxicity","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island","funders":"","keywords":"Calpain; Endoplasmic reticulum; Unfolded protein response; Nephrotoxicity; Chemistry; Kidney; Dithiothreitol; Creatinine; Blood urea nitrogen; Pharmacology; Endocrinology; Toxicity; Apoptosis; Internal medicine; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824703,0.0007595323,0.0005147863,0.0003652395,0.0001772323,0.0002405653,0.0003284753,0.0003813925,0.001537445],"category_scores_gemma":[0.0002341968,0.000219025,0.0003235524,0.0001984482,0.0003490807,0.0004426094,0.0002193575,0.0008136864,0.0003045587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001689521,"about_ca_system_score_gemma":0.0003366465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004423173,"about_ca_topic_score_gemma":0.0006032153,"domain_scores_codex":[0.9998815,0.00001648352,0.00001075034,0.00002595589,0.00002337594,0.00004196492],"domain_scores_gemma":[0.9997815,0.00001978526,0.00008094415,0.00003736081,0.00002544789,0.00005491249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005684989,0.0001090169,0.0001211538,0.00004873811,0.000008720504,0.00007243938,0.00001391973,0.00004784099,0.9971985,0.00005276046,0.00003027872,0.001728215],"study_design_scores_gemma":[0.000067924,0.001358454,0.003134343,0.000006536016,0.00002150081,0.0002300934,0.00002208824,0.0003964185,0.994267,0.00005445364,0.0004372326,0.000004005111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960477,0.000792483,0.002244145,0.0001017904,0.00002882454,0.00002812829,0.0001358587,0.0001256946,0.0004954067],"genre_scores_gemma":[0.9924935,0.001320675,0.002991961,0.00007905899,0.00002491731,0.00005151895,0.0004856627,0.0000405237,0.002512055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537445,"threshold_uncertainty_score":0.005143285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792366145216687,"score_gpt":0.2549199481478943,"score_spread":0.2369962866957274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}