{"id":"W2162587246","doi":"10.1093/toxsci/kfm105","title":"Calpain Inhibition but not Reticulum Endoplasmic Stress Preconditioning Protects Rat Kidneys from p-Aminophenol Toxicity","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island","funders":"","keywords":"Calpain; Endoplasmic reticulum; Unfolded protein response; Nephrotoxicity; Chemistry; Kidney; Dithiothreitol; Creatinine; Blood urea nitrogen; Pharmacology; Endocrinology; Toxicity; Apoptosis; Internal medicine; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009119084,0.0001640736,0.0001403758,0.00005636165,0.0004430613,0.00008009066,0.0001527625,0.0002836533,0.0004144892],"category_scores_gemma":[0.0005313962,0.0001261574,0.00008221641,0.0002077878,0.0004824653,0.00001759928,0.0001030016,0.0001459447,0.00002831989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004867543,"about_ca_system_score_gemma":0.00007147586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000048108,"about_ca_topic_score_gemma":0.0001194449,"domain_scores_codex":[0.9983047,0.0001661495,0.0002840296,0.0005636626,0.0003081109,0.0003733964],"domain_scores_gemma":[0.9993914,0.00008232987,0.000137069,0.0001516106,0.0000594477,0.0001781512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009694514,0.0001181003,0.001166869,0.000006067687,0.000007649959,0.0000062026,0.00002419972,0.0003325074,0.9950321,0.0002539204,0.0004984262,0.002456997],"study_design_scores_gemma":[0.0003871212,0.0006447579,0.01821718,0.00002298998,0.00000704228,0.00001070813,0.0001896026,0.0004519204,0.9781554,0.000587987,0.001119108,0.0002062319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842265,0.00005866012,0.01288822,0.0003714879,0.0003221784,0.0005096431,0.00003978519,0.00005749549,0.001526052],"genre_scores_gemma":[0.99686,0.0000111362,0.001184069,0.0008550808,0.0003969281,0.00005136266,0.0001305466,0.000006487691,0.0005043805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01705031,"threshold_uncertainty_score":0.514455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792366145216687,"score_gpt":0.2549199481478943,"score_spread":0.2369962866957274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}