{"id":"W2162592055","doi":"10.1093/carcin/bgn030","title":"Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)","year":2008,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute","funders":"National Cancer Institute; Canada Research Chairs","keywords":"Carcinogen; Methyltransferase; DNA repair; Mutagenesis; In vivo; Cancer research; O-6-methylguanine-DNA methyltransferase; DNA damage; Deoxyguanosine; Mutation; DNA methyltransferase; Chemistry; DNA methylation; Biology; Methylation; Molecular biology; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565913,0.0004130975,0.0003633951,0.0004832504,0.0001336287,0.0002877462,0.0002365234,0.0004262253,0.001763572],"category_scores_gemma":[0.0001715549,0.0002608921,0.0002825551,0.0001865362,0.0003013964,0.0002021262,0.0002465954,0.0005162649,0.0003941217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002982427,"about_ca_system_score_gemma":0.0001545451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009568813,"about_ca_topic_score_gemma":0.001417376,"domain_scores_codex":[0.9997351,0.00004144092,0.00002676673,0.00008368933,0.0000555856,0.00005748489],"domain_scores_gemma":[0.9996054,0.00005720941,0.0001386502,0.00004160037,0.00003123558,0.0001259195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005057146,0.000008363576,0.000144194,0.000005049033,0.000001971775,0.00001590696,0.000005909615,0.000005750795,0.9996579,0.00001043393,0.000002135118,0.00009172446],"study_design_scores_gemma":[0.000006351292,0.0003475179,0.01510502,0.000004264698,0.00001668307,0.0002378429,0.00003647304,0.0002459634,0.9835203,0.00003304335,0.000442917,0.00000369069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975384,0.0005263133,0.001033967,0.0000362959,0.00001410814,0.00001469865,0.0003272046,0.00006544643,0.0004433941],"genre_scores_gemma":[0.9938194,0.0005156675,0.001181882,0.00004162609,0.000007124944,0.00002888761,0.000583927,0.00004860089,0.003772877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763572,"threshold_uncertainty_score":0.005899787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173786046349048,"score_gpt":0.2489587183689157,"score_spread":0.2272208579054253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}