{"id":"W2162592055","doi":"10.1093/carcin/bgn030","title":"Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)","year":2008,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute","funders":"National Cancer Institute; Canada Research Chairs","keywords":"Carcinogen; Methyltransferase; DNA repair; Mutagenesis; In vivo; Cancer research; O-6-methylguanine-DNA methyltransferase; DNA damage; Deoxyguanosine; Mutation; DNA methyltransferase; Chemistry; DNA methylation; Biology; Methylation; Molecular biology; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004407707,0.0002287416,0.0002348701,0.0001199244,0.000224478,0.00001766882,0.0004958134,0.0001197414,0.00004307838],"category_scores_gemma":[0.0001602403,0.000161327,0.000153318,0.0004510897,0.0001839034,0.000007615776,0.0001551579,0.000087846,0.00001283569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000397931,"about_ca_system_score_gemma":0.0001661111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002718711,"about_ca_topic_score_gemma":0.0004760284,"domain_scores_codex":[0.9981818,0.0001911725,0.000439285,0.0004475734,0.0003636953,0.000376486],"domain_scores_gemma":[0.9988756,0.00008617197,0.0001384368,0.0006673079,0.0001392391,0.00009326539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007157869,0.00005989854,0.1370727,0.000009584575,0.00002419452,0.00001042967,0.0006604164,0.00284177,0.8578652,0.00009217681,0.0002876564,0.001004369],"study_design_scores_gemma":[0.0002883723,0.0001925317,0.2013104,0.000006157447,0.00002276674,0.00001411941,0.0002686514,0.00005625319,0.7946655,0.00008839804,0.002910295,0.00017658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990584,0.00612809,0.001204568,0.0008267214,0.0001962533,0.000472126,0.0000892387,0.000008135145,0.0004909352],"genre_scores_gemma":[0.9981463,0.0004552293,0.0004867441,0.0002873544,0.0002444515,0.00006710503,0.00005399986,0.00003163629,0.0002271909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06423769,"threshold_uncertainty_score":0.6578725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173786046349048,"score_gpt":0.2489587183689157,"score_spread":0.2272208579054253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}