{"id":"W2162610636","doi":"10.1146/annurev-med-043010-144749","title":"Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders","year":2011,"lang":"en","type":"review","venue":"Annual Review of Medicine","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":468,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Heart, Lung, and Blood Institute","keywords":"Endoplasmic reticulum; Unfolded protein response; Neurodegeneration; Disease; Medicine; Bioinformatics; Neuroscience; Cell biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003158614,0.0004067422,0.001923402,0.0001247738,0.00001318981,0.000001508974,0.0003097988,0.0001545259,0.0001018365],"category_scores_gemma":[0.0006198674,0.0002756168,0.0003253058,0.0001890067,0.0004551434,0.000004215531,0.0001507188,0.0001505119,0.000002539259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003915767,"about_ca_system_score_gemma":0.0001716861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001321632,"about_ca_topic_score_gemma":0.00003736607,"domain_scores_codex":[0.9978509,0.0002493211,0.0009826825,0.0004623463,0.0002134886,0.0002412464],"domain_scores_gemma":[0.998423,0.00004784045,0.0006061422,0.0006045694,0.00008193522,0.0002364594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005445562,0.0002597753,0.0007885321,0.2370989,0.0002977521,0.000007311287,0.0000928455,1.976625e-7,0.00003306998,0.001343731,0.001189831,0.7588336],"study_design_scores_gemma":[0.000434801,0.0001564561,0.00007243864,0.1124955,0.001336857,0.000006418635,0.00007079709,4.766174e-7,0.00005564162,0.00007040578,0.8850782,0.0002220842],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002717158,0.9963711,0.000001946292,0.00004296322,0.00006204298,0.000801525,0.0006638731,0.000003492129,0.00178135],"genre_scores_gemma":[0.0008701088,0.9982971,0.00001825698,0.0001797867,0.0001163734,0.0001063595,0.0002889004,0.00004384624,0.00007926035],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8838884,"threshold_uncertainty_score":0.9999696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025537186542684,"score_gpt":0.2992025818200342,"score_spread":0.2889472099546074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}