{"id":"W2162627731","doi":"10.1158/2159-8290.cd-14-0215","title":"Haploinsufficiency of an RB–E2F1–Condensin II Complex Leads to Aberrant Replication and Aneuploidy","year":2014,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Genome instability; Biology; Chromosome instability; Retinoblastoma; Genetics; Aneuploidy; Replication timing; Chromothripsis; Carcinogenesis; Condensin; Cancer research; Chromosome; Molecular biology; DNA replication; Cancer; Chromosome segregation; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150667,0.0001120949,0.0001448041,0.00002631387,0.00006956953,0.00001921259,0.0001354446,0.0000730676,0.000008749316],"category_scores_gemma":[0.00003077118,0.0001069241,0.0000377384,0.00005262925,0.00007854271,0.00001125967,0.0001067191,0.00004033327,0.000001287884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001318635,"about_ca_system_score_gemma":0.00005109595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691137,"about_ca_topic_score_gemma":0.0002788519,"domain_scores_codex":[0.9991622,0.00002785824,0.0001730282,0.000407779,0.00007465369,0.000154499],"domain_scores_gemma":[0.999238,0.000004620448,0.00007370734,0.0005534242,0.00005838152,0.0000718876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004581334,0.0000685374,0.002211487,0.00002628065,0.00001043316,1.566227e-7,0.0000937977,0.000283435,0.9913236,0.000280551,0.0008932785,0.004762554],"study_design_scores_gemma":[0.0006794871,0.001140343,0.06201862,0.00004602188,0.00004296315,0.00001374441,0.00006190669,0.001946429,0.8880379,0.00009693221,0.04553151,0.0003841264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958544,0.0004658096,0.002758249,0.0002181631,0.00008248396,0.00016315,0.0000570595,0.000007831881,0.0003927897],"genre_scores_gemma":[0.9978808,0.0002324517,0.0003709597,0.0007668848,0.0001341212,0.00002091198,0.0001204213,0.00001715523,0.0004562724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032858,"threshold_uncertainty_score":0.4360237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433551818949699,"score_gpt":0.2745913203108248,"score_spread":0.2602558021213279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}