{"id":"W2162627731","doi":"10.1158/2159-8290.cd-14-0215","title":"Haploinsufficiency of an RB–E2F1–Condensin II Complex Leads to Aberrant Replication and Aneuploidy","year":2014,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Genome instability; Biology; Chromosome instability; Retinoblastoma; Genetics; Aneuploidy; Replication timing; Chromothripsis; Carcinogenesis; Condensin; Cancer research; Chromosome; Molecular biology; DNA replication; Cancer; Chromosome segregation; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310935,0.0004522383,0.0001867206,0.0004081118,0.0002127017,0.0002697375,0.0002350477,0.0002790678,0.001573116],"category_scores_gemma":[0.0001407253,0.0001541128,0.0001303411,0.0001784225,0.00037692,0.0001134139,0.0003441325,0.000421319,0.0002854143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004499215,"about_ca_system_score_gemma":0.0002073111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136162,"about_ca_topic_score_gemma":0.001974377,"domain_scores_codex":[0.9998626,0.00001682284,0.00001921074,0.00003178667,0.00004515397,0.0000244323],"domain_scores_gemma":[0.9998015,0.0000493284,0.00007056054,0.00002388297,0.000009387441,0.00004533415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004622172,0.000009434775,0.0002352994,0.00001355473,0.000005527177,0.00006706551,0.000007927017,0.00006635975,0.9988894,0.00007928502,0.00002063531,0.0005593912],"study_design_scores_gemma":[0.00001321943,0.00008937412,0.00381175,0.000004030891,0.00001633829,0.0004631288,0.00001558199,0.0007615802,0.9936139,0.00004379201,0.001163961,0.0000033395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951378,0.0009868008,0.00262225,0.00007667317,0.00001952971,0.0000210228,0.0002096948,0.0001224881,0.0008038594],"genre_scores_gemma":[0.9972409,0.0003675874,0.0008543077,0.00001706253,0.000004396412,0.000009791725,0.0002046931,0.00002779654,0.001273427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001573116,"threshold_uncertainty_score":0.005262613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433551818949699,"score_gpt":0.2745913203108248,"score_spread":0.2602558021213279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}