{"id":"W2162630386","doi":"10.1158/1078-0432.ccr-05-0464","title":"Dendritic Cell Vaccination in Glioblastoma Patients Induces Systemic and Intracranial T-cell Responses Modulated by the Local Central Nervous System Tumor Microenvironment","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":541,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"Jonsson Cancer Center Foundation; National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Medicine; Immune system; Dendritic cell; Cytotoxic T cell; Adverse effect; Vaccination; Immunotherapy; Tumor microenvironment; CTL*; T cell; Immunology; Pathology; CD8; Cancer research; Internal medicine; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165387,0.0002902079,0.0006044841,0.0001057932,0.0001992477,0.0001630747,0.00009045127,0.0002087792,0.0005005677],"category_scores_gemma":[0.0002864974,0.00009286479,0.0001364755,0.0001247305,0.00019532,0.0001022085,0.0001306412,0.0002498516,0.0002061027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003092077,"about_ca_system_score_gemma":0.0003623264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004350641,"about_ca_topic_score_gemma":0.0006606836,"domain_scores_codex":[0.9999152,0.00002648384,0.000006562242,0.0000129364,0.000009985652,0.00002878445],"domain_scores_gemma":[0.9999168,0.00001215097,0.00002702473,0.000005592313,0.000007989699,0.00003038904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02730762,0.005282914,0.3673221,0.0006460745,0.0002835511,0.005621725,0.0004546055,0.00187638,0.2831268,0.0002483697,0.005482366,0.3023475],"study_design_scores_gemma":[0.009900796,0.1517711,0.7056589,0.0001674448,0.0007561666,0.02522821,0.0004973614,0.005723702,0.08607381,0.0006448727,0.01352419,0.00005356765],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986678,0.0005913486,0.0002083114,0.00007553242,0.000009985185,0.00005048328,0.00002547322,0.00001713589,0.0003538353],"genre_scores_gemma":[0.9989826,0.0002897062,0.0003276356,0.00009344605,0.00002489677,0.00003788926,0.0001193654,0.000002633168,0.0001217318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006044841,"threshold_uncertainty_score":0.002243519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518037491735347,"score_gpt":0.3300917701125096,"score_spread":0.3049113951951561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}