{"id":"W2162672763","doi":"10.1261/rna.2905811","title":"Pre-steady-state kinetic analysis of the three <i>Escherichia coli</i> pseudouridine synthases TruB, TruA, and RluA reveals uniformly slow catalysis","year":2011,"lang":"en","type":"article","venue":"RNA","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Northwestern University","keywords":"Biology; Pseudouridine; Escherichia coli; Steady state (chemistry); Biochemistry; Catalysis; Transfer RNA; RNA; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003933578,0.0004303954,0.0006940306,0.0002361797,0.0001275418,0.0005481915,0.0003224236,0.0003975863,0.0004941124],"category_scores_gemma":[0.0006494651,0.0001679348,0.0003706596,0.0002613627,0.0002376049,0.0003447763,0.0001705225,0.0007966392,0.0003914803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004694495,"about_ca_system_score_gemma":0.000261942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008713113,"about_ca_topic_score_gemma":0.0004973401,"domain_scores_codex":[0.9996668,0.00004625416,0.00002631876,0.00008690872,0.0001192518,0.00005439392],"domain_scores_gemma":[0.9994963,0.0001837088,0.00007486509,0.00005959846,0.0001367694,0.00004869585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115449,0.00004114733,0.001508995,0.00005084716,0.00001213349,0.00002797851,0.00003320323,0.0002528272,0.9939189,0.0001331642,0.00003830659,0.003867208],"study_design_scores_gemma":[0.000002951808,0.0001113358,0.006200077,0.000002432012,0.00001045581,0.00008031782,0.00002035011,0.003471616,0.9895839,0.00005382085,0.0004501932,0.00001254848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646368,0.001572809,0.03174671,0.00007217047,0.00002257731,0.00006482733,0.0006258934,0.0003829121,0.0008752776],"genre_scores_gemma":[0.9850049,0.0006213973,0.01183162,0.00003697169,0.000007216334,0.00006091759,0.001218341,0.00005426283,0.001164394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008713113,"threshold_uncertainty_score":0.003406107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608321032314362,"score_gpt":0.2306705424783826,"score_spread":0.214587332155239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}