{"id":"W2162701962","doi":"10.1046/j.1365-2826.2001.00710.x","title":"Modulation of Gonadotropin II Release by K<sup>+</sup> Channel Blockers in Goldfish Gonadotropes: A Novel Stimulatory Action of 4‐Aminopyridine","year":2001,"lang":"en","type":"article","venue":"Journal of Neuroendocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"Internal medicine; Endocrinology; 4-Aminopyridine; Channel blocker; Extracellular; Caffeine; Chemistry; Verapamil; Tetraethylammonium; Gonadotropic cell; Gonadotropin-releasing hormone; Mechanism of action; Hormone; Biology; Luteinizing hormone; Potassium channel; Calcium; Biochemistry; In vitro; Potassium; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001224348,0.0002643435,0.00101983,0.0008482903,0.00003832321,0.000003682758,0.0002029632,0.00008902748,0.00003784362],"category_scores_gemma":[0.0007266011,0.0002468232,0.0002481374,0.0003886165,0.0002104206,0.0002488669,0.00007832638,0.0006120488,0.000002296812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931364,"about_ca_system_score_gemma":0.0001883908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001077373,"about_ca_topic_score_gemma":0.000007329422,"domain_scores_codex":[0.9973327,0.0001448177,0.001294492,0.000353714,0.0004522322,0.0004220743],"domain_scores_gemma":[0.9976349,0.0001372005,0.001102195,0.0004030873,0.0005765687,0.0001460178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005496801,0.001931274,0.03298461,0.0001480884,0.0003078943,0.0007874041,0.0003052401,0.01414638,0.9305351,0.00005981095,0.001961691,0.01133567],"study_design_scores_gemma":[0.03721363,0.01333635,0.7726238,0.0005122765,0.0008048149,0.02182735,0.0008872811,0.0655707,0.06188733,0.0002450536,0.0244469,0.0006444709],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911482,0.001103994,0.0004910458,0.006564747,0.0002416316,0.0003617842,0.00001537874,0.00001660437,0.00005656089],"genre_scores_gemma":[0.9974431,0.001297318,0.0004951844,0.000174623,0.0002691269,0.000005150912,0.000006667455,0.00004046134,0.0002683084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8686478,"threshold_uncertainty_score":0.9999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03008522669305063,"score_gpt":0.2778138839714077,"score_spread":0.247728657278357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}