{"id":"W2162701962","doi":"10.1046/j.1365-2826.2001.00710.x","title":"Modulation of Gonadotropin II Release by K<sup>+</sup> Channel Blockers in Goldfish Gonadotropes: A Novel Stimulatory Action of 4‐Aminopyridine","year":2001,"lang":"en","type":"article","venue":"Journal of Neuroendocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"Internal medicine; Endocrinology; 4-Aminopyridine; Channel blocker; Extracellular; Caffeine; Chemistry; Verapamil; Tetraethylammonium; Gonadotropic cell; Gonadotropin-releasing hormone; Mechanism of action; Hormone; Biology; Luteinizing hormone; Potassium channel; Calcium; Biochemistry; In vitro; Potassium; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694209,0.000308704,0.0005788093,0.0001156938,0.0001548518,0.0004994741,0.0002330061,0.0003894479,0.0007503919],"category_scores_gemma":[0.0002330167,0.0001880581,0.0003788255,0.00009098893,0.0002925402,0.0003993343,0.0002714857,0.0005623167,0.0002273072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000390732,"about_ca_system_score_gemma":0.0003562121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001349606,"about_ca_topic_score_gemma":0.002781683,"domain_scores_codex":[0.9998763,0.00001469523,0.00002481044,0.00002601908,0.00002746197,0.00003084004],"domain_scores_gemma":[0.9998764,0.0000329844,0.00002930986,0.00001531556,0.00001964977,0.00002631103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101242,0.000004151368,0.0001355048,0.00003365805,0.000002703749,0.00004613683,0.00001054505,0.0000118782,0.999348,0.000006690005,0.00000528152,0.0002941928],"study_design_scores_gemma":[0.0000935856,0.001054935,0.01814347,0.00001092298,0.00005273968,0.0002079827,0.00009944593,0.0004966058,0.9782645,0.00002640781,0.001534627,0.00001491205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974121,0.001230888,0.0004266067,0.0000903017,0.00002259699,0.00001968632,0.0001226834,0.00002920204,0.0006458639],"genre_scores_gemma":[0.9955955,0.001169524,0.001755438,0.0001074626,0.00002520747,0.00005665508,0.0002024522,0.0000204135,0.001067307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001349606,"threshold_uncertainty_score":0.002835035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03008522669305063,"score_gpt":0.2778138839714077,"score_spread":0.247728657278357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}