{"id":"W2162735751","doi":"10.2174/156652306775515538","title":"Targeting DNA Repair Proteins: A Promising Avenue for Cancer Gene Therapy","year":2006,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital","funders":"","keywords":"DNA repair; Homologous recombination; Genetic enhancement; Cancer; Cancer research; Biology; Gene; DNA; Cancer cell; DNA damage; Genome instability; Radiation therapy; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005594926,0.0008733661,0.00125412,0.0001190705,0.0002162093,0.00006979376,0.0005902075,0.000545078,0.00002510246],"category_scores_gemma":[0.00003384902,0.0007364642,0.001308522,0.0001932242,0.00006613184,0.000006680531,0.0001078656,0.0002923871,0.000009615825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001263739,"about_ca_system_score_gemma":0.0006968405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001386462,"about_ca_topic_score_gemma":0.000004187619,"domain_scores_codex":[0.9966635,0.0002275901,0.0008301107,0.001268613,0.000278348,0.0007318595],"domain_scores_gemma":[0.9980184,0.00001982467,0.0007107848,0.0009370823,0.000190024,0.0001238644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008759042,0.0002085332,0.000003030739,0.00215111,0.0004229911,0.000002283225,0.00002952822,0.000007599543,0.0952379,0.000007423613,0.0033142,0.8985278],"study_design_scores_gemma":[0.0009001197,0.0003556204,6.26115e-7,0.001367663,0.000110318,0.00001132408,0.000001819397,0.00002038527,0.08989654,0.00006732073,0.9065002,0.000768022],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002705601,0.9879876,0.001509265,0.00001234163,0.001370137,0.005867147,0.0003935998,0.000139621,0.00001472504],"genre_scores_gemma":[0.00001812881,0.9838968,0.004084877,0.0000574643,0.00362128,0.005293496,0.002342331,0.0003012421,0.0003843624],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.903186,"threshold_uncertainty_score":0.9995086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06154839178120794,"score_gpt":0.3574347242085726,"score_spread":0.2958863324273647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}