{"id":"W2162738633","doi":"10.1139/jpn.0423","title":"Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response","year":2004,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Ottawa Mental Health Centre; Mental Health Research Canada; University of Ottawa","funders":"","keywords":"Anxiolytic; Antidepressant; Pharmacology; Serotonin; Substance P; 5-HT receptor; Antagonism; Norepinephrine; Autoreceptor; Receptor; Medicine; Internal medicine; Chemistry; Hippocampus; Neuropeptide; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001605616,0.0002202085,0.0003758635,0.0001125249,0.0001015157,0.0002383557,0.0001334636,0.0002802422,0.002190121],"category_scores_gemma":[0.0002137984,0.00007995111,0.0001495973,0.00005743983,0.0002550086,0.0001907897,0.0001079125,0.0004618999,0.0002712136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221168,"about_ca_system_score_gemma":0.0001979068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003180911,"about_ca_topic_score_gemma":0.0006657115,"domain_scores_codex":[0.9999079,0.00002533241,0.000005849597,0.00001081407,0.00001810318,0.00003203379],"domain_scores_gemma":[0.9999101,0.00002041243,0.00002159201,0.000007273587,0.000005899618,0.00003482639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006647973,0.0002895072,0.001349853,0.00008652757,0.00003589973,0.0002907311,0.00001916717,0.0001351438,0.9671251,0.0002387292,0.0001134206,0.02366802],"study_design_scores_gemma":[0.001919178,0.05636668,0.2304699,0.00005716905,0.0005126396,0.004301453,0.0002524578,0.002115635,0.6930425,0.001192627,0.00973086,0.0000388743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922008,0.004803021,0.0003480058,0.0002621078,0.00003332717,0.00002159302,0.0000974739,0.000011978,0.002221756],"genre_scores_gemma":[0.9959798,0.002697533,0.000254812,0.0001274802,0.00004132201,0.00001252969,0.0001002018,0.000004040848,0.0007822791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002190121,"threshold_uncertainty_score":0.007326663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301014333406788,"score_gpt":0.2694351221656939,"score_spread":0.2564249788316261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}