{"id":"W2162741953","doi":"10.1007/s00438-003-0900-9","title":"The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans","year":2003,"lang":"en","type":"article","venue":"Molecular Genetics and Genomics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"University of Missouri","keywords":"Biology; Caenorhabditis elegans; Sterol; Moulting; Ecdysone; Hydroxysteroid; Hormone; Mutant; Steroid hormone; Cholesterol; Steroid; Gene; Sterol regulatory element-binding protein; Cell biology; Enzyme; Biochemistry; Larva; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459731,0.0005971771,0.0003719504,0.0004622335,0.0005036207,0.000688778,0.0004071876,0.0005091815,0.0005102467],"category_scores_gemma":[0.0002463895,0.0004044734,0.0002357779,0.0001547492,0.0005510558,0.0003000451,0.0003580779,0.0005955796,0.0008304268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006197501,"about_ca_system_score_gemma":0.0005539601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001962018,"about_ca_topic_score_gemma":0.003711999,"domain_scores_codex":[0.9997906,0.00001174328,0.00001874388,0.00004573997,0.0001020962,0.00003105523],"domain_scores_gemma":[0.9997334,0.00003949678,0.00008755643,0.00003434309,0.00003398525,0.00007115199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001264568,0.000008935863,0.0003894877,0.0000271346,0.000006467727,0.0002272697,0.000008640682,0.000175076,0.9968873,0.0002439183,0.00008357973,0.001815847],"study_design_scores_gemma":[0.00001034379,0.00004071581,0.00367171,0.000008705698,0.00002282478,0.0004375889,0.00002284231,0.001461614,0.9905562,0.0002056743,0.003548397,0.00001330642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881617,0.003413697,0.004657549,0.0001923926,0.0001073609,0.00001147122,0.0006187081,0.0004906184,0.002346425],"genre_scores_gemma":[0.9893029,0.001149483,0.003349375,0.00007006822,0.00001516014,0.000008997706,0.000877092,0.000129741,0.005097079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962018,"threshold_uncertainty_score":0.004496634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008498270868248435,"score_gpt":0.2147731723168458,"score_spread":0.2062749014485973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}