{"id":"W2162788150","doi":"10.14814/phy2.12251","title":"Downregulation of cystathionine<i>β</i>-synthase and cystathionine<i>γ</i>-lyase expression stimulates inflammation in kidney ischemia-reperfusion injury","year":2014,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Manitoba; St. Boniface Hospital","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cystathionine beta synthase; Cystathionine gamma-lyase; Downregulation and upregulation; Inflammation; Ischemia; ATP synthase; Medicine; Enzyme; Kidney; Internal medicine; Chemistry; Biochemistry; Cysteine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005879972,0.0002375809,0.000340085,0.0000815093,0.0000712254,0.00001328349,0.0001078506,0.0003306165,0.00002612303],"category_scores_gemma":[0.002137895,0.0001883368,0.00007875625,0.000123846,0.0001939607,0.0000163961,0.0002726582,0.0001490459,0.000001664724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000175838,"about_ca_system_score_gemma":0.0000484993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001874518,"about_ca_topic_score_gemma":0.000002322616,"domain_scores_codex":[0.9980399,0.0002220439,0.0006793955,0.0006278221,0.0001724085,0.0002584535],"domain_scores_gemma":[0.9987345,0.00008232188,0.0004249821,0.0004896388,0.0001291941,0.0001393181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002821788,0.00008769421,0.005544905,0.00004682987,0.000007686624,0.00001079294,0.00003390628,0.0004814079,0.990886,0.00005527521,0.0004131314,0.002150144],"study_design_scores_gemma":[0.0004766568,0.0005220071,0.01670751,0.0001076332,0.000009496174,0.00004795937,0.00001429158,0.0008739713,0.9774193,0.00200967,0.001573607,0.0002378916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983184,0.0001337658,0.0008304856,0.00009096355,0.0001172557,0.0002521875,0.000007992128,0.00002804283,0.0002209331],"genre_scores_gemma":[0.9970194,0.0001096066,0.002026457,0.0001392691,0.0001866713,0.0000386989,0.0004276621,0.00001652314,0.00003573094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01346674,"threshold_uncertainty_score":0.7680152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008757921644138284,"score_gpt":0.2544690572314062,"score_spread":0.245711135587268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}