{"id":"W2162877239","doi":"10.1371/journal.pone.0007112","title":"Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"PIM1; Kinase; Kinome; Protein kinase domain; Computational biology; Biology; Serine; Bioinformatics; Chemistry; Cell biology; Biochemistry; Phosphorylation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002689046,0.00008319274,0.0002075346,0.00003900927,0.00002329006,0.00000530057,0.00006885105,0.00004089043,0.0003275962],"category_scores_gemma":[0.000006557984,0.00004979526,0.00002088547,0.0001791348,0.00003196243,0.00003477275,0.000009153589,0.0001285087,6.936302e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003249481,"about_ca_system_score_gemma":0.00005551572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004663691,"about_ca_topic_score_gemma":0.0001946743,"domain_scores_codex":[0.9993773,0.00001784811,0.0001170941,0.0001219279,0.0002467237,0.0001191751],"domain_scores_gemma":[0.9995732,0.000005265393,0.00004952888,0.000265114,0.00005513312,0.00005178769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004727106,0.0007838571,0.001772596,0.00002979595,0.0000296287,0.000005989605,0.0004975069,0.000001464917,0.9956014,0.0004645988,0.00001752134,0.0003229285],"study_design_scores_gemma":[0.00279937,0.001542822,0.06401063,0.000249838,0.00007313752,0.000009317049,0.0001903976,0.00008407063,0.9293448,0.00153505,0.000060273,0.0001002655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984396,0.00004698943,0.00001232727,0.001002337,0.00001400905,0.0002928536,0.00002273094,0.00001688544,0.000152267],"genre_scores_gemma":[0.9977829,0.000004876852,0.001361049,0.00061886,0.0001401248,0.000001455282,0.00001143563,0.0000124146,0.00006687518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06625657,"threshold_uncertainty_score":0.3586949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02566523226393111,"score_gpt":0.2322677900500427,"score_spread":0.2066025577861116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}