{"id":"W2162908443","doi":"10.1177/0091270007308615","title":"Assessment of Pharmacokinetics and Pharmacodynamic Effects Related to Abuse Potential of a Unique Oral Osmotic‐Controlled Extended‐Release Methylphenidate Formulation in Humans","year":2007,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Methylphenidate; Placebo; Stimulant; Crossover study; Pharmacodynamics; Pharmacokinetics; Pharmacology; Anesthesia; Controlled release; Medicine; Attention deficit hyperactivity disorder; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006421755,0.0004489466,0.0006913369,0.0001619184,0.0002322985,0.000332085,0.0002116711,0.0004554279,0.001037836],"category_scores_gemma":[0.0009164434,0.0004149459,0.0003111906,0.0001297893,0.0004793354,0.0004807193,0.0001483656,0.0005810451,0.000193489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001820728,"about_ca_system_score_gemma":0.00033529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003786184,"about_ca_topic_score_gemma":0.0006291236,"domain_scores_codex":[0.9996767,0.0001424378,0.00002119526,0.00005662934,0.00007258001,0.00003050606],"domain_scores_gemma":[0.9996575,0.00009100109,0.0001171116,0.00003610492,0.00002608254,0.00007210927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.3326924,0.01962561,0.0320261,0.0009029187,0.0009942891,0.0008376072,0.0007017103,0.00162544,0.4418619,0.000272939,0.000972529,0.1674866],"study_design_scores_gemma":[0.03472909,0.6991103,0.1949912,0.00004610435,0.0009276565,0.002655098,0.0002916772,0.004685457,0.0574275,0.0002392374,0.004797002,0.00009970104],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975863,0.0009491942,0.0007095914,0.00003962035,0.00002893806,0.0002454908,0.0001273931,0.00001672447,0.0002968099],"genre_scores_gemma":[0.997182,0.0009584524,0.0009998934,0.00009883183,0.00005185304,0.000193709,0.0001756429,0.000007321839,0.0003323844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037836,"threshold_uncertainty_score":0.003471911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03448215947735757,"score_gpt":0.4752178458980692,"score_spread":0.4407356864207116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}