{"id":"W2162919259","doi":"10.1172/jci14080","title":"The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":878,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; U.S. Public Health Service; National Institutes of Health","keywords":"Diabetic cardiomyopathy; Internal medicine; Endocrinology; Peroxisome proliferator-activated receptor; Beta oxidation; Heart failure; Cardiomyopathy; Biology; Phenotype; Fatty acid metabolism; Glucose uptake; Fatty acid; Metabolism; Receptor; Insulin; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817521,0.000346933,0.0002333814,0.0003176081,0.0002136599,0.0003331927,0.0001230101,0.000259115,0.001436671],"category_scores_gemma":[0.0001548113,0.0001757965,0.000193577,0.0002495236,0.0003093162,0.0001414468,0.0002591501,0.0006708106,0.0003933957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001806264,"about_ca_system_score_gemma":0.0001535729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002037923,"about_ca_topic_score_gemma":0.00030111,"domain_scores_codex":[0.9998236,0.00003580131,0.0000226885,0.00003280495,0.00004392245,0.00004112928],"domain_scores_gemma":[0.9998372,0.00001864114,0.00005703428,0.00002802689,0.0000083472,0.00005070098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004396034,0.00006592385,0.0009904267,0.000024539,0.000008487702,0.0004087132,0.00001383207,0.00008512138,0.9963295,0.0002841403,0.00005371667,0.001296118],"study_design_scores_gemma":[0.0003191421,0.003381403,0.05698288,0.0000445734,0.0001011999,0.01049416,0.0002257656,0.001937365,0.9121323,0.0008089043,0.01354268,0.00002959495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933372,0.0007776764,0.002373048,0.0001443514,0.00008480546,0.00004258012,0.0003686893,0.00009625081,0.002775441],"genre_scores_gemma":[0.9929934,0.0008886604,0.002307771,0.0001231905,0.00002095292,0.00007051571,0.0006506309,0.00003584365,0.002909051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001436671,"threshold_uncertainty_score":0.004806161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07587762791124153,"score_gpt":0.3234650288524766,"score_spread":0.2475874009412351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}