{"id":"W2162921620","doi":"10.1371/journal.pbio.1001708","title":"Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy","year":2013,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Cancer Institute; National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Howard Hughes Medical Institute","keywords":"Autophagy; ATG8; Glycogen; Biology; Myopathy; Lysosome; Cell biology; Glycogen synthase; Chloroquine; Bafilomycin; Glycogen debranching enzyme; Biochemistry; Genetics; Enzyme; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008940055,0.00009776139,0.0003129285,0.000158807,0.00001510903,0.000003201187,0.0001060223,0.0001134267,0.0004140293],"category_scores_gemma":[0.0005619019,0.00007948909,0.00002378728,0.0002305322,0.00006379699,0.0000438636,0.0001230879,0.0001331355,0.0002413003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003482277,"about_ca_system_score_gemma":0.00004068407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004147955,"about_ca_topic_score_gemma":0.00007247126,"domain_scores_codex":[0.9990809,0.00004827714,0.0002094827,0.0002634706,0.00009748397,0.0003004118],"domain_scores_gemma":[0.9994416,0.00008722572,0.00003444691,0.0001809383,0.0001229597,0.0001328178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000168414,0.0001879222,0.04638975,0.00006727513,0.00002545213,0.00001126658,0.0003776859,7.540243e-7,0.9370619,0.000262688,0.0000874724,0.01535942],"study_design_scores_gemma":[0.003634933,0.003328329,0.5898729,0.0001635671,0.0000312794,0.00008987029,0.0003251872,0.002209326,0.3923765,0.002554334,0.005092855,0.0003209504],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931111,0.003102142,0.000002795192,0.001512766,0.00001973287,0.0006405409,0.000009344983,0.0000216559,0.001579869],"genre_scores_gemma":[0.9987778,0.0001918367,0.0001816924,0.0003245521,0.00004279101,0.00009683271,0.00001124197,0.0000134202,0.0003598052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5446854,"threshold_uncertainty_score":0.4533331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497448613809518,"score_gpt":0.2779498492970588,"score_spread":0.2629753631589637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}