{"id":"W2162928407","doi":"10.2174/1568026043387836","title":"Inhibitors of 3C Cysteine Proteinases from Picornaviridae","year":2004,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Natural Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Picornavirus; Picornaviridae; Enzyme; Biochemistry; Cysteine; Rhinovirus; Biology; Chemistry; Virology; Virus; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002257655,0.0003841162,0.001797656,0.0001722547,0.00003712383,0.000008082545,0.0002567908,0.0005028212,0.0002804507],"category_scores_gemma":[0.000452512,0.0002975826,0.0003742026,0.0004554771,0.0003651678,0.00003552732,0.0001474505,0.001957152,0.00002194939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004137691,"about_ca_system_score_gemma":0.001079552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171505,"about_ca_topic_score_gemma":0.000002479224,"domain_scores_codex":[0.997743,0.00005975797,0.0009900066,0.0004542476,0.0004165792,0.0003364764],"domain_scores_gemma":[0.9987448,0.00007896872,0.0003265124,0.000593181,0.0001230797,0.0001334737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002892233,0.0004820567,0.0003599922,0.06691142,0.0001291937,0.0001068414,0.00003266239,1.577678e-7,0.0002174471,0.00001543247,0.000197112,0.9315187],"study_design_scores_gemma":[0.001204888,0.0002799901,0.00005705568,0.1294786,0.0005184582,0.0001062921,0.00003554808,0.000001065504,0.001445327,0.0001043636,0.8665243,0.0002441419],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003990994,0.9934813,0.000009414118,0.00007095677,0.0005490655,0.0007477199,0.0000493863,0.00002788628,0.001073255],"genre_scores_gemma":[0.0006647969,0.9968637,0.00005345168,0.000004579405,0.001255821,0.000154821,0.000497308,0.00003323113,0.0004722999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9312746,"threshold_uncertainty_score":0.9999476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08030012419379993,"score_gpt":0.4155885129530493,"score_spread":0.3352883887592493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}