{"id":"W2162930641","doi":"10.1261/rna.7108205","title":"High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation","year":2004,"lang":"en","type":"article","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministry of Education, Culture, Sports, Science and Technology; Japan Health Sciences Foundation","keywords":"Biology; Translation (biology); Messenger RNA; RNA; Eukaryotic translation; Eukaryotic initiation factor; Cell biology; RNA-binding protein; Initiation factor; EIF4E; Molecular biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396633,0.0007327799,0.0005055231,0.0002840472,0.0001764325,0.0002529588,0.0003476792,0.0006739473,0.001472014],"category_scores_gemma":[0.0002955995,0.0002944256,0.0004226966,0.0001761549,0.000271382,0.0001420857,0.0002250049,0.0006892242,0.0005174453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004004412,"about_ca_system_score_gemma":0.0001624767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003008044,"about_ca_topic_score_gemma":0.000426654,"domain_scores_codex":[0.9993864,0.000167222,0.00003669488,0.0001358516,0.000150528,0.0001233011],"domain_scores_gemma":[0.9998344,0.00007183523,0.0000381138,0.00002153343,0.00001520391,0.00001878525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004869429,0.00005163853,0.0000354197,0.00003128289,0.000006084706,0.0000184257,0.000008712589,0.0001052403,0.9984735,0.00006643348,0.00004842181,0.001106148],"study_design_scores_gemma":[0.00001537236,0.0003311665,0.0003839327,0.000002605841,0.00000809878,0.0001018913,0.000002487389,0.0007629852,0.9970868,0.00001767978,0.001282564,0.000004562268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705977,0.004109079,0.0200622,0.0002960995,0.0001673922,0.0002003334,0.0002597964,0.0004667789,0.003840629],"genre_scores_gemma":[0.981209,0.001453585,0.01144886,0.0002498667,0.00003927878,0.0001832073,0.0005934395,0.00005562763,0.004767122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472014,"threshold_uncertainty_score":0.004924417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737114898619161,"score_gpt":0.2746363379884443,"score_spread":0.2472651890022527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}