{"id":"W2162930641","doi":"10.1261/rna.7108205","title":"High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation","year":2004,"lang":"en","type":"article","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministry of Education, Culture, Sports, Science and Technology; Japan Health Sciences Foundation","keywords":"Biology; Translation (biology); Messenger RNA; RNA; Eukaryotic translation; Eukaryotic initiation factor; Cell biology; RNA-binding protein; Initiation factor; EIF4E; Molecular biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007956757,0.00009260826,0.000082373,0.00004837745,0.00009033622,0.00004250019,0.00005415879,0.00007907765,0.0000066391],"category_scores_gemma":[0.00003486286,0.0000779133,0.00002767387,0.00004905747,0.00002997535,0.00001207415,0.00001671196,0.00006289098,0.000002130154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001648298,"about_ca_system_score_gemma":0.00004741236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005578092,"about_ca_topic_score_gemma":0.0001969545,"domain_scores_codex":[0.9994213,0.00001754755,0.0001058495,0.000188262,0.00008648478,0.0001805585],"domain_scores_gemma":[0.9997312,0.00001215602,0.00004247235,0.00009272045,0.00004973877,0.00007167272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002269871,0.00001906003,0.0005218549,0.00003558041,0.00002080975,0.000001280322,0.00008595618,0.00007498114,0.9887081,0.0001252266,0.00002315641,0.01015704],"study_design_scores_gemma":[0.001217974,0.0005736754,0.002319239,0.00004451803,0.000008028094,0.000004977678,0.00005890663,0.00004835921,0.9951102,0.0001273811,0.0003627179,0.0001240557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903746,0.0001459563,0.008741851,0.0002914259,0.00003194698,0.0002261125,0.00003826227,0.000009723542,0.0001401058],"genre_scores_gemma":[0.9978325,0.00006829231,0.001659701,0.00004763746,0.0001087725,0.00001731728,0.0001181677,0.00001474953,0.0001328278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01003299,"threshold_uncertainty_score":0.3177212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02737114898619161,"score_gpt":0.2746363379884443,"score_spread":0.2472651890022527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}