{"id":"W2162941545","doi":"10.1073/pnas.071552198","title":"X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Medical Research Council Canada; Medical Research Council; Andrew W. Mellon Foundation; Howard Hughes Medical Institute","keywords":"Poly(A)-binding protein; Biology; Conserved sequence; Protein domain; Binding protein; Plasma protein binding; B3 domain; Cell biology; Peptide sequence; RNA-binding protein; Molecular biology; Messenger RNA; Genetics; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046837,0.0007578491,0.0004805747,0.0002293278,0.0004009465,0.0005021801,0.0005560332,0.0008668433,0.004183213],"category_scores_gemma":[0.0001741802,0.0002744513,0.0003519286,0.0004171823,0.0002604398,0.0003869433,0.0001825345,0.0009259564,0.002353815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008261442,"about_ca_system_score_gemma":0.0004016868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002357885,"about_ca_topic_score_gemma":0.001707869,"domain_scores_codex":[0.9999349,0.000008705576,0.000003271498,0.00001979537,0.00002425933,0.000009020498],"domain_scores_gemma":[0.9999278,0.00001280909,0.00001583824,0.000004933399,0.00001369094,0.00002497205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001890369,0.0003356852,0.004410553,0.001002309,0.000129686,0.003618418,0.000359427,0.005192691,0.9369969,0.004285747,0.01652709,0.02525113],"study_design_scores_gemma":[0.0006449049,0.001290509,0.2052532,0.0002169081,0.0003885005,0.009551505,0.0006505434,0.04012186,0.3752824,0.00284533,0.3635902,0.0001642184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8985668,0.03810664,0.01463045,0.002317742,0.0006406275,0.0001953239,0.01617219,0.001236771,0.02813344],"genre_scores_gemma":[0.8870434,0.007660232,0.02005263,0.0005707865,0.0001097763,0.00008115976,0.05360556,0.0001913225,0.03068514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004183213,"threshold_uncertainty_score":0.01399422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224146289145702,"score_gpt":0.3079608583581294,"score_spread":0.2857193954666724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}