{"id":"W2162944731","doi":"10.2337/diabetes.52.7.1683","title":"Poly (ADP-Ribose) Polymerase Inhibition Prevents Spontaneous and Recurrent Autoimmune Diabetes in NOD Mice by Inducing Apoptosis of Islet-Infiltrating Leukocytes","year":2003,"lang":"en","type":"article","venue":"Diabetes","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; National Institutes of Health; University of Alberta","keywords":"Insulitis; Poly ADP ribose polymerase; NOD mice; Nod; Islet; Apoptosis; Nicotinamide; Beta cell; Diabetes mellitus; PARP inhibitor; Endocrinology; Medicine; Cancer research; Internal medicine; NAD+ kinase; Immunology; Biology; Polymerase; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004718112,0.0003107667,0.0006107371,0.0002708692,0.0001111083,0.00003815944,0.00007074973,0.0001705811,0.0001266437],"category_scores_gemma":[0.0002967559,0.000320766,0.00009469711,0.0004115435,0.0001806669,0.0002113789,0.00003095398,0.0003309516,0.000005052016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898974,"about_ca_system_score_gemma":0.0001164047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008879056,"about_ca_topic_score_gemma":0.000004460579,"domain_scores_codex":[0.9977707,0.0002144763,0.0007087029,0.0004499688,0.0003202771,0.0005358804],"domain_scores_gemma":[0.9988862,0.0003332556,0.0003118001,0.0002656989,0.00007238288,0.000130652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005160814,0.0003087903,0.05237166,0.0002588299,0.00007434479,0.000007845404,0.0005710231,0.000001548333,0.936384,0.00004257928,0.0003068826,0.009620927],"study_design_scores_gemma":[0.002529229,0.0004259848,0.00404833,0.00146033,0.00006181566,0.00001576695,0.000222376,0.0001443875,0.9903417,0.0001614682,0.0002945026,0.0002941364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984976,0.01340235,0.00000773605,0.0003606041,0.0002140273,0.0004699911,0.00008219322,0.00006460684,0.0004225053],"genre_scores_gemma":[0.9983683,0.000153387,0.0006107674,0.0004618271,0.0000780556,0.00009868013,0.0001146879,0.00004766041,0.00006669671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05395771,"threshold_uncertainty_score":0.9999244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084670831892246,"score_gpt":0.2522604792678235,"score_spread":0.2414137709489011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}