{"id":"W2162955464","doi":"10.1016/j.cell.2015.08.027","title":"Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":353,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Institute of Allergy and Infectious Diseases; Klarman Cell Observatory, Broad Institute; National Institutes of Health","keywords":"Biology; Immune system; Pathogen; Bacteria; Antigenic variation; Phenotype; Salmonella; Host (biology); Population; Phase variation; Cell; Microbiology; Cell type; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273714,0.0001346439,0.0004066297,0.0001788753,0.0001556073,0.0008532075,0.0002962154,0.0004272103,0.0007691379],"category_scores_gemma":[0.0004428025,0.0002203911,0.0001783114,0.0002292045,0.0003059906,0.0005673289,0.0003712879,0.0008823234,0.0003217548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003466683,"about_ca_system_score_gemma":0.0001512616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003128863,"about_ca_topic_score_gemma":0.0005378954,"domain_scores_codex":[0.9997304,0.00003536172,0.00001252107,0.00009554935,0.00007218567,0.00005399017],"domain_scores_gemma":[0.9995692,0.0001742579,0.00008391359,0.00006926579,0.00004858352,0.00005470765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004374678,0.000007664223,0.0009431478,0.000009978212,0.000003877108,0.00002841303,0.00001256466,0.0004265173,0.9969925,0.0002877112,0.00004658175,0.001197327],"study_design_scores_gemma":[0.00002194547,0.0001633418,0.1202902,0.000006753802,0.00003619643,0.0005317445,0.0002845743,0.06006544,0.8127161,0.003105954,0.002737362,0.00004029963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855115,0.0003757602,0.01232703,0.0001266304,0.00002786116,0.000009327649,0.0003813332,0.0001348681,0.00110561],"genre_scores_gemma":[0.9981428,0.0001001247,0.001198049,0.00004386472,0.00001466269,0.000007826353,0.0001198581,0.00002763707,0.0003451779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008532075,"threshold_uncertainty_score":0.002573013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900444221603946,"score_gpt":0.2429116051949206,"score_spread":0.2239071629788811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}