{"id":"W2163037142","doi":"10.1371/journal.pgen.1004285","title":"Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; University Health Network; Ontario Institute for Cancer Research; Public Health Ontario; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University Health Centre; McGill University; University of Toronto; Centre hospitalier universitaire de Québec; Royal Victoria Hospital; Université de Montréal; Royal Victoria Regional Health Centre; Université Laval","funders":"Medical Research and Materiel Command; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Cancer Council Tasmania; National Human Genome Research Institute; Cancer Council Victoria; Medical Research Council; Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Agence Nationale de la Recherche; National Breast Cancer Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Agency for Science, Technology and Research; Academy of Finland; King's College London; Fonds Wetenschappelijk Onderzoek; Cancerfonden; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Breast Cancer Campaign; Breast Cancer Research Foundation; University of Cambridge; KWF Kankerbestrijding; Herlev Hospital; Fondation du cancer du sein du Québec; Wellcome Trust; Cancer Research UK; National Institute for Health and Care Research; National Institutes of Health; Deutsche Gesetzliche Unfallversicherung; David F. and Margaret T. Grohne Family Foundation; U.S. Army; University of Westminster; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Sundhed og Sygdom, Det Frie Forskningsråd; Associazione Italiana per la Ricerca sul Cancro; Itä-Suomen Yliopisto; Susan G. Komen for the Cure; Cancer Care Ontario; European Commission; Robert Bosch Stiftung; Helsingin ja Uudenmaan Sairaanhoitopiiri; U.S. Department of Health and Human Services","keywords":"Biology; Genetic predisposition; Lobular carcinoma; Carcinoma in situ; Breast cancer; In situ; Invasive lobular carcinoma; Genetics; Evolutionary biology; Carcinoma; Ductal carcinoma; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007875353,0.0005905053,0.0007220918,0.001785202,0.0004619305,0.0006264001,0.0004186241,0.0006687499,0.005311805],"category_scores_gemma":[0.002314236,0.0003390848,0.0006976154,0.001893933,0.0003928688,0.0001887622,0.0006190349,0.0004552113,0.0003913605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002952143,"about_ca_system_score_gemma":0.0002500282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003114062,"about_ca_topic_score_gemma":0.002812144,"domain_scores_codex":[0.9990554,0.000246197,0.0001030297,0.000316959,0.0001525399,0.0001258476],"domain_scores_gemma":[0.998725,0.0004192102,0.0004300688,0.0001494709,0.00007571012,0.0002004939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001197879,0.0001377038,0.9716489,0.0001295153,0.000990861,0.002131336,0.0002629723,0.0001515565,0.01550947,0.0003049375,0.00044364,0.007091329],"study_design_scores_gemma":[0.0000478111,0.0001856074,0.9931383,0.00002657984,0.0004083069,0.004088828,0.0001282754,0.0002107898,0.0007368954,0.0002238161,0.0007933509,0.00001146721],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956548,0.001432177,0.0005650583,0.00008129056,0.0000177147,0.00003624046,0.000864822,0.00003191811,0.001315903],"genre_scores_gemma":[0.9977733,0.000453223,0.0003757517,0.00005200704,0.00003891809,0.00002081995,0.0007228927,0.00001103996,0.0005520109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005311805,"threshold_uncertainty_score":0.01776981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006139655036776298,"score_gpt":0.1984786233827829,"score_spread":0.1923389683460066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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