{"id":"W2163037142","doi":"10.1371/journal.pgen.1004285","title":"Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; University Health Network; Ontario Institute for Cancer Research; Public Health Ontario; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University Health Centre; McGill University; University of Toronto; Centre hospitalier universitaire de Québec; Royal Victoria Hospital; Université de Montréal; Royal Victoria Regional Health Centre; Université Laval","funders":"Medical Research and Materiel Command; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Cancer Council Tasmania; National Human Genome Research Institute; Cancer Council Victoria; Medical Research Council; Canadian Institutes of Health Research; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Agence Nationale de la Recherche; National Breast Cancer Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Agency for Science, Technology and Research; Academy of Finland; King's College London; Fonds Wetenschappelijk Onderzoek; Cancerfonden; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Breast Cancer Campaign; Breast Cancer Research Foundation; University of Cambridge; KWF Kankerbestrijding; Herlev Hospital; Fondation du cancer du sein du Québec; Wellcome Trust; Cancer Research UK; National Institute for Health and Care Research; National Institutes of Health; Deutsche Gesetzliche Unfallversicherung; David F. and Margaret T. Grohne Family Foundation; U.S. Army; University of Westminster; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Sundhed og Sygdom, Det Frie Forskningsråd; Associazione Italiana per la Ricerca sul Cancro; Itä-Suomen Yliopisto; Susan G. Komen for the Cure; Cancer Care Ontario; European Commission; Robert Bosch Stiftung; Helsingin ja Uudenmaan Sairaanhoitopiiri; U.S. Department of Health and Human Services","keywords":"Biology; Genetic predisposition; Lobular carcinoma; Carcinoma in situ; Breast cancer; In situ; Invasive lobular carcinoma; Genetics; Evolutionary biology; Carcinoma; Ductal carcinoma; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003182829,0.000110887,0.0001161632,0.00002637043,0.00003461081,0.000006052765,0.0001181507,0.00005896707,0.000001634931],"category_scores_gemma":[0.0000291104,0.00008929076,0.00003020442,0.00007838516,0.00006990103,9.990587e-7,0.0001848739,0.00003232413,0.000001749402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001478649,"about_ca_system_score_gemma":0.00002589117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001935188,"about_ca_topic_score_gemma":0.0004448849,"domain_scores_codex":[0.9993518,0.00005129073,0.0001344194,0.0002209798,0.0001009293,0.0001405854],"domain_scores_gemma":[0.9995536,0.00001269157,0.00004520048,0.0002865342,0.00005713102,0.00004486689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003593387,0.00006548468,0.4971046,0.0000304812,0.00003234076,6.004241e-7,0.0001929908,0.0001364726,0.5012997,0.00001049642,0.00006842234,0.001022447],"study_design_scores_gemma":[0.0002852042,0.00009744029,0.5840406,0.00002247153,0.00002905069,0.00001410539,0.0000279796,0.00003443922,0.4152707,0.00004543711,0.00006545442,0.0000670455],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984114,0.0007465493,0.00006642055,0.0002744372,0.00004285464,0.0002257468,0.00002977778,0.0000025282,0.0002002787],"genre_scores_gemma":[0.9991359,0.00007315029,0.0004427088,0.0001867456,0.00009754812,0.00002914238,0.000008220512,0.00001383197,0.00001272052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08693597,"threshold_uncertainty_score":0.3641171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006139655036776298,"score_gpt":0.1984786233827829,"score_spread":0.1923389683460066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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