{"id":"W2163081237","doi":"10.2337/db07-1608","title":"<i>Slc11a1</i>Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens","year":2008,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Wellcome Trust","keywords":"Antigen presentation; Biology; NOD mice; Immunology; Major histocompatibility complex; Antigen; Immune system; Antigen-presenting cell; Antigen processing; Pancreatic islets; T cell; Cell biology; Islet; Autoimmunity; Endocrinology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251506,0.0001347937,0.0001711292,0.00002483735,0.0001750851,0.00002394997,0.0001368418,0.00007095651,0.000005611945],"category_scores_gemma":[0.00008769925,0.000107096,0.00005903852,0.0001077288,0.0001865931,0.00001062255,0.00006739653,0.00005549044,0.000001616878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000463892,"about_ca_system_score_gemma":0.00003995903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001116278,"about_ca_topic_score_gemma":8.040076e-7,"domain_scores_codex":[0.9990886,0.0001101601,0.0002022244,0.0002203191,0.0001163557,0.0002623649],"domain_scores_gemma":[0.9995308,0.00005654645,0.0001504654,0.0001776322,0.00005074669,0.00003378751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000291449,0.00005054138,0.03791828,0.00004084193,0.000043112,2.334355e-7,0.0002474217,0.00001450207,0.9595872,4.915132e-7,0.0008985583,0.001169636],"study_design_scores_gemma":[0.000408466,0.0001547732,0.02151339,0.00002961194,0.00002979903,4.261022e-7,0.0001640319,0.0002031632,0.9745608,0.00001845721,0.002772571,0.000144495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869324,0.01249354,0.00002768455,0.0001531057,0.00003477174,0.0001629812,0.00002798223,0.00001203538,0.0001554978],"genre_scores_gemma":[0.9983712,0.0009048245,0.00007887658,0.0001649046,0.00002403385,0.00003053757,0.00006824915,0.00001954077,0.0003378285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01640489,"threshold_uncertainty_score":0.436725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005447757325726001,"score_gpt":0.2153086472016277,"score_spread":0.2098608898759017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}