{"id":"W2163094978","doi":"10.1186/1465-9921-7-26","title":"Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo","year":2006,"lang":"en","type":"article","venue":"Respiratory Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Transfection; Small interfering RNA; In vivo; Respiratory epithelium; Biology; Molecular biology; Cationic liposome; In vitro; Epithelium; Cell biology; Cell culture; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006813013,0.0005038533,0.0004867396,0.0002770128,0.0001562889,0.0005128752,0.0003101873,0.000714156,0.00123069],"category_scores_gemma":[0.0003342145,0.000273219,0.0003153572,0.0001175129,0.0003874763,0.0003620521,0.0003185767,0.0007151105,0.0007485067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004365975,"about_ca_system_score_gemma":0.0003299891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005237308,"about_ca_topic_score_gemma":0.0006281745,"domain_scores_codex":[0.9994025,0.0001298897,0.00005126405,0.0001593798,0.0001646339,0.0000923533],"domain_scores_gemma":[0.9996793,0.0001093397,0.00007573109,0.00004488126,0.00004893467,0.00004184566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003979513,0.00001389097,0.0000571058,0.00003236503,0.000003328851,0.00002368739,0.00001274683,0.00003077224,0.9990805,0.00004743606,0.00002177605,0.000636627],"study_design_scores_gemma":[0.00001455352,0.0004021009,0.0007301331,0.000006281194,0.00001225867,0.0001662802,0.00001941603,0.0008900132,0.9966066,0.00002559343,0.001123936,0.000003001139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691489,0.003559486,0.02421379,0.0001989714,0.0000895366,0.0001475411,0.0002782692,0.0003048543,0.002058596],"genre_scores_gemma":[0.9831427,0.001436498,0.009107275,0.0001669112,0.00001615822,0.0001730516,0.0005595408,0.00009518499,0.005302538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123069,"threshold_uncertainty_score":0.004117072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622343826929759,"score_gpt":0.3038534524486505,"score_spread":0.277630014179353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}