{"id":"W2163096595","doi":"10.1517/14712598.2013.779249","title":"New developments in lentiviral vector design, production and purification","year":2013,"lang":"en","type":"review","venue":"Expert Opinion on Biological Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO","funders":"","keywords":"Genetic enhancement; Lentivirus; Viral vector; Vector (molecular biology); Retrovirus; Bioproduction; Vectors in gene therapy; Computational biology; Recombinant DNA; Gene delivery; Biology; Virology; Biotechnology; Gene; Human immunodeficiency virus (HIV); Virus; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004298338,0.000426002,0.0005893738,0.0001455848,0.00007356858,0.0000473462,0.0003230241,0.0006007422,0.00008542793],"category_scores_gemma":[0.0001044556,0.0002864448,0.0001364348,0.0002029028,0.00008094087,0.000006596299,0.00007082525,0.00025878,0.00007684505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000656383,"about_ca_system_score_gemma":0.0002111491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009433617,"about_ca_topic_score_gemma":0.00000205989,"domain_scores_codex":[0.9974288,0.0007359957,0.0004148473,0.0008987814,0.0001741459,0.0003474595],"domain_scores_gemma":[0.9992389,0.00004120863,0.0001559148,0.0004058048,0.0000430684,0.0001150896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005149856,0.000103158,0.000007724213,0.00002208377,0.0000583666,4.479206e-7,0.00002221198,5.324074e-7,0.01253275,0.00001422408,0.002286413,0.9844371],"study_design_scores_gemma":[0.0003500657,0.002470418,0.00006118821,0.0004275019,3.256515e-7,0.000005899888,0.000005438927,5.60517e-7,0.01089431,0.00002891574,0.9853966,0.0003588219],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000680721,0.9967459,0.0001907101,0.0001392496,0.0004163964,0.001752164,0.000003913643,0.0000236727,0.00004726929],"genre_scores_gemma":[0.0002204693,0.9965799,0.001167403,0.0001451828,0.000693508,0.0006228812,0.0003356971,0.00004396765,0.0001910043],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9840783,"threshold_uncertainty_score":0.9999588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2138463043600271,"score_gpt":0.4105336812077076,"score_spread":0.1966873768476805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}