{"id":"W2163148038","doi":"10.1016/j.addr.2009.11.020","title":"Nanotechnology applications for improved delivery of antiretroviral drugs to the brain","year":2009,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":208,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; U.S. Department of Defense","keywords":"Nanocarriers; Blood–brain barrier; Drug delivery; Solid lipid nanoparticle; Drug; Raltegravir; Pharmacology; Targeted drug delivery; Bioavailability; Chemistry; Medicine; Virus; Central nervous system; Virology; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004864986,0.001080371,0.001350963,0.001803123,0.0003699647,0.0008964433,0.0009191441,0.001516726,0.003221455],"category_scores_gemma":[0.0003508795,0.0003577834,0.0005206353,0.001266612,0.0005689765,0.001193326,0.0006104364,0.001748859,0.002105653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007177329,"about_ca_system_score_gemma":0.000704369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000971286,"about_ca_topic_score_gemma":0.002870249,"domain_scores_codex":[0.9998537,0.00001679983,0.00001285252,0.00002437544,0.00007441144,0.00001778959],"domain_scores_gemma":[0.9998149,0.00009231214,0.00002227266,0.000005892353,0.00005019096,0.00001441103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000782136,0.00009144707,0.0001077845,0.006136259,0.00004980319,0.000388762,0.00004394563,0.0004143681,0.0166082,0.005271482,0.02341246,0.9473972],"study_design_scores_gemma":[0.00002950126,0.000126605,0.0005143062,0.001396063,0.00006245654,0.002546156,0.00004251837,0.0002724438,0.006602967,0.002595884,0.9857839,0.00002709504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001915686,0.9968419,0.000570819,0.0001837083,0.0004739832,0.000006619831,0.000006417317,0.00001234252,0.001712561],"genre_scores_gemma":[0.001136401,0.9957566,0.0007003914,0.0001713843,0.0002932717,0.000009450167,0.00001632369,0.000002651107,0.001913483],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003221455,"threshold_uncertainty_score":0.01077682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02494184588680516,"score_gpt":0.3282090268166217,"score_spread":0.3032671809298166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}