{"id":"W2163184659","doi":"10.1124/jpet.113.206284","title":"Concurrent Agonism of Adenosine A2B and Glucocorticoid Receptors in Human Airway Epithelial Cells Cooperatively Induces Genes with Anti-Inflammatory Potential: A Novel Approach to Treat Chronic Obstructive Pulmonary Disease","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Glucocorticoid receptor; Glucocorticoid; Dexamethasone; Agonist; Adenosine receptor; Biology; Adenosine; Receptor; Pharmacology; Endocrinology; Internal medicine; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158043,0.0003034932,0.0004140435,0.0001912975,0.0002276922,0.0004506624,0.0001939872,0.0002898567,0.001522783],"category_scores_gemma":[0.0001587064,0.0001700145,0.000461236,0.0001925184,0.0002980346,0.0001749354,0.0002503936,0.0007127115,0.0002967991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002846734,"about_ca_system_score_gemma":0.0003927943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000595826,"about_ca_topic_score_gemma":0.002877019,"domain_scores_codex":[0.999709,0.00006950053,0.00002245432,0.00005261066,0.00006341707,0.00008307145],"domain_scores_gemma":[0.9999092,0.00002353787,0.00001555809,0.00002018644,0.000008440881,0.00002305401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003424103,0.00005365613,0.0001437356,0.00003378123,0.000007728401,0.00004844654,0.00001673473,0.00005245119,0.9971179,0.0001678457,0.00008144612,0.001933882],"study_design_scores_gemma":[0.0001299541,0.001924551,0.004601406,0.00001074408,0.00006688116,0.0003691122,0.0001626024,0.0007046988,0.9875041,0.0001316467,0.004384052,0.0000102017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868019,0.006520017,0.002974308,0.0006431289,0.0002879112,0.00006793452,0.0003552305,0.0001024793,0.00224715],"genre_scores_gemma":[0.9959249,0.00126163,0.001238687,0.00008855396,0.00005105036,0.00004201596,0.000154622,0.000008942634,0.001229459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522783,"threshold_uncertainty_score":0.00509423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138677547130259,"score_gpt":0.2768829006402329,"score_spread":0.263015145927207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}