{"id":"W2163221461","doi":"10.1042/bst20120160","title":"Evolutionary selection for protein aggregation","year":2012,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Protein aggregation; Protein folding; Proteome; Protein function; Function (biology); Human proteome project; Biology; Computational biology; Chemistry; Cell biology; Bioinformatics; Genetics; Proteomics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008966693,0.0005075933,0.0008961248,0.0006270868,0.0003805382,0.0008923043,0.0006570601,0.001320457,0.001957238],"category_scores_gemma":[0.0006913504,0.0001515472,0.0003897822,0.0007612399,0.001034922,0.0009476313,0.0008637745,0.0009326813,0.0009723484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007425058,"about_ca_system_score_gemma":0.000607077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004765058,"about_ca_topic_score_gemma":0.0005525929,"domain_scores_codex":[0.9996523,0.00009806237,0.00002108812,0.0001060437,0.00007729922,0.00004514378],"domain_scores_gemma":[0.9997678,0.0001032775,0.00003085052,0.00001767039,0.00004971205,0.00003069355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001944,0.00009959177,0.004163263,0.007918877,0.0003464851,0.002845331,0.0004257542,0.001530193,0.03018524,0.04123794,0.01366489,0.897388],"study_design_scores_gemma":[0.00005724244,0.0003848748,0.0198898,0.001973426,0.0002191366,0.01003414,0.0004692727,0.0007409542,0.01130734,0.02337069,0.9314772,0.00007587645],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01273319,0.9688612,0.003843624,0.0027941,0.0005920363,0.00002101284,0.00006571014,0.00004750488,0.01104163],"genre_scores_gemma":[0.06544802,0.9259241,0.001988054,0.001426835,0.0005746844,0.00003896574,0.0001280299,0.00002056066,0.004450698],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001957238,"threshold_uncertainty_score":0.00654763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02457967944846113,"score_gpt":0.2949772378649722,"score_spread":0.270397558416511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}