{"id":"W2163290737","doi":"10.1016/j.clml.2011.09.201","title":"5.47 Tyrosine Kinase Inhibitor, Gefitinib, is Cytotoxic Against Zeta-Chain-Associated Protein Kinase 70-Positive but not Zeta-Chain-Associated Protein Kinase 70-Negative CLL Cells","year":2011,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Gefitinib; Tyrosine kinase; Syk; Cancer research; Cytotoxic T cell; LYN; Kinase; Proto-oncogene tyrosine-protein kinase Src; Tyrosine-kinase inhibitor; Protein kinase B; Chemistry; Medicine; Epidermal growth factor receptor; Signal transduction; Cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314641,0.0003710835,0.0004130002,0.0004126651,0.0003701053,0.0004230606,0.000258835,0.0003882587,0.003046168],"category_scores_gemma":[0.0001980793,0.0001394256,0.0003010982,0.0002322136,0.0002270544,0.000255529,0.0001464772,0.0005083981,0.0007338343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000462576,"about_ca_system_score_gemma":0.0003644123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022522,"about_ca_topic_score_gemma":0.00284683,"domain_scores_codex":[0.9998403,0.00002366287,0.0000100214,0.00001136831,0.00003013354,0.00008455764],"domain_scores_gemma":[0.9999059,0.00002654107,0.00001240719,0.000009504772,0.000007299121,0.00003835782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007131512,0.001104214,0.00410103,0.0003053362,0.0001364328,0.0007858958,0.00009046541,0.001258458,0.9252186,0.001056009,0.005980063,0.0528319],"study_design_scores_gemma":[0.002306287,0.01553291,0.07705331,0.00005350897,0.0002856511,0.007052782,0.0001850894,0.006157841,0.8603109,0.000458182,0.03055222,0.00005126335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984599,0.005207765,0.0004982284,0.0004295476,0.0001508097,0.00003731105,0.0003312979,0.0001854296,0.008560594],"genre_scores_gemma":[0.9963596,0.001051895,0.0003254402,0.00007199087,0.00003634318,0.00001582154,0.0006406175,0.00001060176,0.001487646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003046168,"threshold_uncertainty_score":0.01019043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04686491458162083,"score_gpt":0.3049367709307811,"score_spread":0.2580718563491603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}