{"id":"W2163299200","doi":"10.1158/1078-0432.ccr-06-1892","title":"Phase I Pharmacokinetic and Pharmacodynamic Study of 17-<i>N</i>-Allylamino-17-Demethoxygeldanamycin in Pediatric Patients with Recurrent or Refractory Solid Tumors: A Pediatric Oncology Experimental Therapeutics Investigators Consortium Study","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Medicine; Pharmacokinetics; Toxicity; Pharmacodynamics; Internal medicine; Hsp90 inhibitor; Adverse effect; Pediatric cancer; Pharmacology; Gastroenterology; Oncology; Heat shock protein; Cancer; Hsp90; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006638972,0.0003637992,0.0007268381,0.0006423625,0.0001548153,0.00002824732,0.0006339098,0.0002690797,0.0001053757],"category_scores_gemma":[0.000643341,0.0002876037,0.00007534696,0.001224297,0.0005613072,0.00002028799,0.0006913893,0.001559969,0.000002958417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280285,"about_ca_system_score_gemma":0.001859526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002328346,"about_ca_topic_score_gemma":0.001306668,"domain_scores_codex":[0.9923562,0.002589684,0.001573748,0.00117773,0.001249526,0.001053078],"domain_scores_gemma":[0.997026,0.0008223209,0.0002986742,0.0005943389,0.0006579647,0.0006006795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01684904,0.04366386,0.8855996,0.0001288264,0.0002105069,0.0002083356,0.001153567,0.00001697721,0.03072119,3.146685e-7,0.0006240082,0.02082377],"study_design_scores_gemma":[0.1112626,0.2488351,0.5825477,0.00007431851,0.0004489866,0.000009446219,0.009473624,0.000356723,0.04258123,0.000007629768,0.002991031,0.001411702],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928406,0.00252539,0.00001502502,0.00005167369,0.0001687732,0.004223969,0.00003580247,0.000012414,0.0001262862],"genre_scores_gemma":[0.9968496,0.001605424,0.00009149253,0.000123687,0.0005701428,0.0005326616,0.0000228005,0.00007000929,0.0001342132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3030519,"threshold_uncertainty_score":0.9999576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1486361598675103,"score_gpt":0.5409377296812757,"score_spread":0.3923015698137655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}