{"id":"W2163299200","doi":"10.1158/1078-0432.ccr-06-1892","title":"Phase I Pharmacokinetic and Pharmacodynamic Study of 17-<i>N</i>-Allylamino-17-Demethoxygeldanamycin in Pediatric Patients with Recurrent or Refractory Solid Tumors: A Pediatric Oncology Experimental Therapeutics Investigators Consortium Study","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Medicine; Pharmacokinetics; Toxicity; Pharmacodynamics; Internal medicine; Hsp90 inhibitor; Adverse effect; Pediatric cancer; Pharmacology; Gastroenterology; Oncology; Heat shock protein; Cancer; Hsp90; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008549466,0.001159394,0.001331253,0.000214965,0.0002612673,0.0005391306,0.0005359271,0.0005923891,0.001150084],"category_scores_gemma":[0.0005697143,0.00034193,0.0006235903,0.000386968,0.0006751755,0.0003801802,0.0001969345,0.002446273,0.0003455629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001169937,"about_ca_system_score_gemma":0.002001477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285098,"about_ca_topic_score_gemma":0.002244253,"domain_scores_codex":[0.9996397,0.0001921285,0.00001520881,0.00005341935,0.00004887253,0.00005054567],"domain_scores_gemma":[0.9993752,0.00009129531,0.0001859968,0.00005545135,0.000050116,0.0002420293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3001016,0.07411984,0.05206275,0.001067861,0.002619876,0.001440928,0.001338835,0.01719788,0.3216827,0.001078375,0.009525563,0.2177637],"study_design_scores_gemma":[0.1592773,0.7159498,0.05455402,0.00007825107,0.0010253,0.002327407,0.0001865798,0.005348701,0.04809325,0.0003449686,0.01276156,0.0000528354],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959245,0.001209855,0.0008695421,0.0001807935,0.0000207138,0.0006142178,0.0004838754,0.00006164063,0.0006349135],"genre_scores_gemma":[0.9909242,0.00177435,0.003056123,0.0003886382,0.0000607009,0.001281432,0.001625349,0.00004757172,0.0008416217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331253,"threshold_uncertainty_score":0.008488536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1486361598675103,"score_gpt":0.5409377296812757,"score_spread":0.3923015698137655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}