{"id":"W2163331125","doi":"10.1016/s1474-4422(12)70234-x","title":"Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies","year":2012,"lang":"en","type":"review","venue":"The Lancet Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":487,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Center for Advancing Translational Sciences; Medical Research Council; Fonds Wetenschappelijk Onderzoek; STROKE-Riksförbundet; Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; National Institute on Aging; National Institute for Health and Care Research; Centre for Cognitive Ageing and Cognitive Epidemiology; Office of Research on Women's Health; National Heart, Lung, and Blood Institute; Deutsche Migräne- und Kopfschmerzgesellschaft e.V.; Vlaamse regering; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Austrian Science Fund; Lunds Universitet; Economic and Social Research Council; Skånes universitetssjukhus; University of Edinburgh; Bundesministerium für Bildung und Forschung; Heart and Stroke Foundation of Canada; National Heart Foundation of Australia; Engineering and Physical Sciences Research Council; AstraZeneca; Vetenskapsrådet; Canadian Stroke Network","keywords":"Genome-wide association study; Meta-analysis; Ischaemic stroke; Stroke (engine); Genetic association; Medicine; Computational biology; Biology; Genetics; Internal medicine; Genotype; Gene; Single-nucleotide polymorphism; Ischemia; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01442092,0.002337766,0.009881101,0.004755202,0.0009235712,0.002268145,0.001878288,0.001605861,0.002471661],"category_scores_gemma":[0.02494815,0.001423352,0.02684591,0.005950015,0.0003989786,0.0008053496,0.002413439,0.001438857,0.0002828907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009566073,"about_ca_system_score_gemma":0.001511046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01065289,"about_ca_topic_score_gemma":0.0174436,"domain_scores_codex":[0.9873959,0.007343299,0.001454975,0.00252178,0.0008902195,0.0003938017],"domain_scores_gemma":[0.9844556,0.009258511,0.001703973,0.003040647,0.001121666,0.0004195296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004891758,0.00002542416,0.08575655,0.007412041,0.8889202,0.0003496396,0.0001222714,0.001547548,0.001204257,0.0001996111,0.002136283,0.00743442],"study_design_scores_gemma":[0.00187721,0.0003227184,0.08702414,0.001111457,0.9038435,0.0006323708,0.00009114988,0.001741576,0.0004104325,0.000629655,0.00225521,0.00006048774],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4392327,0.5080776,0.02298031,0.002513459,0.0008564268,0.0005942655,0.02337698,0.0009807358,0.00138747],"genre_scores_gemma":[0.9398398,0.03431733,0.01401819,0.0007689722,0.000380693,0.0008422692,0.008870365,0.0002949072,0.0006675488],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01442092,"threshold_uncertainty_score":0.07626599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176022425036502,"score_gpt":0.3533843524118924,"score_spread":0.2357821099082421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}