{"id":"W2163357887","doi":"10.1158/0008-5472.can-08-2110","title":"ADP-Ribosylation Factor 6 Regulates Glioma Cell Invasion through the IQ-Domain GTPase-Activating Protein 1-Rac1–Mediated Pathway","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Institutes of Health","keywords":"IQGAP1; RAC1; Glioma; Cell migration; Small interfering RNA; Cancer research; Small GTPase; Biology; ADP ribosylation factor; Gene knockdown; Cell biology; GTPase-activating protein; Scaffold protein; Signal transduction; Cell; Chemistry; Transfection; Cell culture; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008268587,0.0003312196,0.0001188623,0.0002588217,0.0001960424,0.0002566071,0.0001259774,0.0001572696,0.0007906401],"category_scores_gemma":[0.00009477616,0.00008493787,0.0001689521,0.00008768927,0.000209196,0.0001607916,0.00015113,0.0003392374,0.0004379635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512816,"about_ca_system_score_gemma":0.0001280807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004667424,"about_ca_topic_score_gemma":0.0006867576,"domain_scores_codex":[0.9999197,0.0000204344,0.000003602033,0.000009991611,0.00002297011,0.00002328633],"domain_scores_gemma":[0.99994,0.000007880985,0.00001736467,0.000004470649,0.00001082737,0.00001939593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038675,0.00002311556,0.0002644692,0.00002551138,0.000002213289,0.00009208044,0.00001954485,0.00009888705,0.9975879,0.0002215283,0.00008487581,0.001475941],"study_design_scores_gemma":[0.00002898297,0.0002511033,0.01790443,0.000009215791,0.00001858487,0.0007725612,0.000078805,0.005047456,0.9686742,0.0004128788,0.006792393,0.000009425956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924814,0.002285506,0.00207774,0.0001971061,0.00001961964,0.00000904207,0.000104213,0.00009418962,0.002731311],"genre_scores_gemma":[0.9962967,0.001062121,0.001078517,0.00003012386,0.000008883511,0.000008170709,0.0001762797,0.00001048524,0.001328691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007906401,"threshold_uncertainty_score":0.002644897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0599631677353139,"score_gpt":0.3495196387075413,"score_spread":0.2895564709722274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}