{"id":"W2163357887","doi":"10.1158/0008-5472.can-08-2110","title":"ADP-Ribosylation Factor 6 Regulates Glioma Cell Invasion through the IQ-Domain GTPase-Activating Protein 1-Rac1–Mediated Pathway","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Institutes of Health","keywords":"IQGAP1; RAC1; Glioma; Cell migration; Small interfering RNA; Cancer research; Small GTPase; Biology; ADP ribosylation factor; Gene knockdown; Cell biology; GTPase-activating protein; Scaffold protein; Signal transduction; Cell; Chemistry; Transfection; Cell culture; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006153692,0.0002021627,0.0001454039,0.00006124812,0.0004152633,0.00009175442,0.000479373,0.0002057683,0.0001326497],"category_scores_gemma":[0.0005916856,0.0001539914,0.00009061783,0.0004875751,0.0001878775,0.00001769875,0.0001610633,0.0003773014,0.00002802752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001160568,"about_ca_system_score_gemma":0.0004287983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001158619,"about_ca_topic_score_gemma":0.00002013618,"domain_scores_codex":[0.9975294,0.0004560068,0.000262718,0.0005498113,0.0006270601,0.000574956],"domain_scores_gemma":[0.998664,0.00009887656,0.0001167572,0.0006601329,0.0003288602,0.0001314118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002372475,0.00008508404,0.0001920851,0.00003289399,0.00001515587,0.00001284429,0.0003579388,0.00007924407,0.9947949,0.00006487234,0.001467675,0.002660041],"study_design_scores_gemma":[0.0005769556,0.0003066788,0.0009464018,0.00008973402,0.000002770261,0.000001987404,0.0002297423,0.00003634529,0.9855845,0.001160251,0.0108687,0.0001959287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994981,0.001944637,0.0002115976,0.001060517,0.00007834786,0.0009141481,0.00008780652,0.00003751284,0.0006844492],"genre_scores_gemma":[0.9981297,0.00005555154,0.0003018148,0.0001711215,0.0004607813,0.0002347791,0.0001652206,0.00003905304,0.0004420076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00940103,"threshold_uncertainty_score":0.6279585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0599631677353139,"score_gpt":0.3495196387075413,"score_spread":0.2895564709722274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}