{"id":"W2163375473","doi":"10.1158/1078-0432.ccr-14-1437","title":"miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple Myeloma","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital","funders":"","keywords":"Multiple myeloma; Cancer research; Clonogenic assay; Apoptosis; microRNA; Transfection; Viability assay; In vivo; Plasma cell leukemia; Biology; Cell culture; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496589,0.0002875869,0.0002378819,0.000234496,0.0001247034,0.0002759387,0.0001583305,0.000196443,0.0009132004],"category_scores_gemma":[0.0001200461,0.0001148802,0.0002433398,0.0001383331,0.0002361887,0.0001434952,0.0001936198,0.0004364715,0.0003262161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004270735,"about_ca_system_score_gemma":0.0003002077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003218963,"about_ca_topic_score_gemma":0.000467932,"domain_scores_codex":[0.9998717,0.00001217741,0.000009954696,0.00002144944,0.00006233516,0.00002227486],"domain_scores_gemma":[0.9999381,0.00001075257,0.00002318578,0.000006134616,0.000008824543,0.00001292072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105141,0.00002284269,0.0003024303,0.00004302706,0.000005874675,0.00005175448,0.000008777682,0.000083434,0.9976882,0.0001360087,0.00003786439,0.00151469],"study_design_scores_gemma":[0.00001979406,0.0002638239,0.002085411,0.000004246983,0.00002193298,0.0003435377,0.00001891746,0.0007812429,0.993847,0.00005667117,0.002554684,0.000002781234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859707,0.004010534,0.007386934,0.0001654966,0.00004378782,0.00006334183,0.000313063,0.0001993986,0.001846692],"genre_scores_gemma":[0.9935023,0.001173864,0.003197387,0.00006886831,0.00001046425,0.0000382241,0.000429172,0.00001823809,0.001561487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009132004,"threshold_uncertainty_score":0.003098607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2832308845321098,"score_gpt":0.5013554029379498,"score_spread":0.21812451840584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}