{"id":"W2163394083","doi":"10.1016/s1474-4422(09)70237-6","title":"Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial","year":2009,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":370,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"Bayer Schering","keywords":"Medicine; Expanded Disability Status Scale; Multiple sclerosis; Clinically isolated syndrome; Hazard ratio; Internal medicine; Clinical endpoint; Placebo; Interferon beta-1b; Interferon beta-1a; McDonald criteria; Clinical trial; Interferon beta; Physical therapy; Confidence interval; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003793318,0.002375784,0.004647372,0.0004859459,0.0008431884,0.001627345,0.001218756,0.003522272,0.003694603],"category_scores_gemma":[0.002983592,0.000674971,0.004421582,0.0004476008,0.001602037,0.001589006,0.0007806189,0.004946634,0.0008969752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001080758,"about_ca_system_score_gemma":0.001483592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002046324,"about_ca_topic_score_gemma":0.002284243,"domain_scores_codex":[0.9984999,0.000780741,0.00006707459,0.0001897112,0.0000915438,0.0003709728],"domain_scores_gemma":[0.997339,0.0009155443,0.0005480127,0.0002748753,0.0001185533,0.0008041461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.98522,0.004746724,0.0007733207,0.0001255533,0.0007469746,0.00004256149,0.00003988228,0.0001952777,0.001041083,0.00004149408,0.0002693106,0.006757888],"study_design_scores_gemma":[0.8895671,0.09781314,0.009747441,0.00006240117,0.001269401,0.00005543822,0.00003003154,0.000361862,0.000395426,0.0002313065,0.0004361302,0.00003034394],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923499,0.004210604,0.0002598867,0.0006719689,0.0003566704,0.0003640704,0.0005639028,0.00004598889,0.001176998],"genre_scores_gemma":[0.9943568,0.001264784,0.000395839,0.000948208,0.0004286685,0.0005893877,0.0007916906,0.00001384367,0.001210855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004647372,"threshold_uncertainty_score":0.02006119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09622116179535428,"score_gpt":0.375427040034515,"score_spread":0.2792058782391607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}