{"id":"W2163394083","doi":"10.1016/s1474-4422(09)70237-6","title":"Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial","year":2009,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":370,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"Bayer Schering","keywords":"Medicine; Expanded Disability Status Scale; Multiple sclerosis; Clinically isolated syndrome; Hazard ratio; Internal medicine; Clinical endpoint; Placebo; Interferon beta-1b; Interferon beta-1a; McDonald criteria; Clinical trial; Interferon beta; Physical therapy; Confidence interval; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000408786,0.0003010172,0.001456069,0.00007442552,0.00006789252,0.000004061647,0.0002254735,0.0001181881,0.00002418399],"category_scores_gemma":[0.0002577248,0.0001277474,0.0003934807,0.0001570325,0.0006296365,0.00003500715,0.0001080844,0.0002734813,0.000003397077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000744536,"about_ca_system_score_gemma":0.00005850025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001437232,"about_ca_topic_score_gemma":0.0003344053,"domain_scores_codex":[0.9975869,0.0006705587,0.0005904151,0.0004188131,0.0003539724,0.0003793286],"domain_scores_gemma":[0.9968193,0.001632818,0.0004117438,0.0008949679,0.00015532,0.00008590381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6105201,0.003535156,0.3414127,0.00005207044,0.0006735128,0.00002443477,0.001035221,0.00002074882,0.005669894,0.000003025786,0.00002469702,0.03702853],"study_design_scores_gemma":[0.1005816,0.1526303,0.7217748,0.0002009828,0.0004654357,0.000006760333,0.00001020728,0.00004609946,0.02420104,0.000002853902,0.0000179052,0.00006194879],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938284,0.0002172245,0.00000556132,0.002767914,0.0001299449,0.002889692,0.0001153294,0.0000168675,0.00002907724],"genre_scores_gemma":[0.9982901,0.001024539,0.00002003985,0.00012072,0.0002445561,0.0002458448,0.000007988358,0.00002028245,0.00002588654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5099385,"threshold_uncertainty_score":0.5209389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09622116179535428,"score_gpt":0.375427040034515,"score_spread":0.2792058782391607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}