{"id":"W2163399712","doi":"10.2337/db13-0941","title":"Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Opportunity for Arterial Repair","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Libin Cardiovascular Institute of Alberta; University of Ottawa","funders":"","keywords":"GSK-3; Progenitor cell; Endothelial progenitor cell; Glycogen synthase; GSK3B; Cathepsin; Apoptosis; Cathepsin B; Cancer research; Endocrinology; Medicine; Senescence; Internal medicine; Stem cell; Glycogen; Pharmacology; Kinase; Biology; Cell biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576248,0.0002359992,0.0002838019,0.0001861787,0.00008046932,0.0002960759,0.0001154843,0.0001407033,0.0009216777],"category_scores_gemma":[0.00006569095,0.00008309325,0.0002294531,0.0001345384,0.0001559788,0.0001707459,0.0001485771,0.0005048032,0.0001150297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663424,"about_ca_system_score_gemma":0.0002018244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001876217,"about_ca_topic_score_gemma":0.0005256725,"domain_scores_codex":[0.9999534,0.000008853346,0.000004832989,0.000008064309,0.00001060827,0.00001423675],"domain_scores_gemma":[0.999972,0.000003262658,0.000008089176,0.00000333077,0.000003062836,0.00001025041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006001336,0.0001315968,0.0005223731,0.0001477236,0.0000211197,0.00007074756,0.00001224034,0.00008104071,0.9858279,0.0001928547,0.000126982,0.0122651],"study_design_scores_gemma":[0.0001932308,0.001896184,0.01281722,0.00002632854,0.00008306801,0.0004812382,0.00003597848,0.0008082273,0.9778326,0.0001497216,0.005668235,0.000007869466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873797,0.008257295,0.002424561,0.0002543586,0.00004493697,0.00002920732,0.0002054417,0.0000821069,0.001322444],"genre_scores_gemma":[0.993876,0.003488427,0.001417625,0.00005938831,0.00001317144,0.0000287527,0.0001674411,0.000006910329,0.0009422215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009216777,"threshold_uncertainty_score":0.003083289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807086075617876,"score_gpt":0.2398330375312262,"score_spread":0.2217621767750475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}