{"id":"W2163399712","doi":"10.2337/db13-0941","title":"Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Opportunity for Arterial Repair","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Libin Cardiovascular Institute of Alberta; University of Ottawa","funders":"","keywords":"GSK-3; Progenitor cell; Endothelial progenitor cell; Glycogen synthase; GSK3B; Cathepsin; Apoptosis; Cathepsin B; Cancer research; Endocrinology; Medicine; Senescence; Internal medicine; Stem cell; Glycogen; Pharmacology; Kinase; Biology; Cell biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718595,0.0002047841,0.0001814354,0.00002738884,0.0001575947,0.00004498565,0.00007588793,0.0001425799,0.0001035532],"category_scores_gemma":[0.00003669407,0.000189122,0.0001644905,0.00004288441,0.000118538,0.00001253929,0.00005455731,0.00004271649,0.00001054067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002503682,"about_ca_system_score_gemma":0.00008208417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003079388,"about_ca_topic_score_gemma":0.000004521663,"domain_scores_codex":[0.9988697,0.00004795758,0.00022784,0.0004177068,0.0001162691,0.0003205548],"domain_scores_gemma":[0.9993318,0.00003156831,0.0001110751,0.0002564783,0.0001227562,0.0001462697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006755745,0.0002352075,0.007233457,0.00007954246,0.00008448149,2.435624e-7,0.00002407024,0.00000169539,0.9883943,0.00001521166,0.0007292543,0.003135018],"study_design_scores_gemma":[0.001349499,0.0004117655,0.007136102,0.00002053905,0.00007406084,0.000001568732,0.00003131947,0.0004518451,0.9784441,0.0003450229,0.01141997,0.0003142022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960803,0.001048544,0.001218402,0.00009536146,0.0003271946,0.0007561814,0.0003859674,0.00003103582,0.00005696753],"genre_scores_gemma":[0.9967123,0.00003908805,0.000665615,0.0005412665,0.0006490572,0.0008140691,0.000323633,0.00003476309,0.0002201597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01069071,"threshold_uncertainty_score":0.7712172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807086075617876,"score_gpt":0.2398330375312262,"score_spread":0.2217621767750475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}