{"id":"W2163501136","doi":"10.1211/jpp.58.11.0016","title":"In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of <i>Rubus idaeus</i> and its fortified fractions","year":2006,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Rubus; In vitro; Monolayer; Caco-2; Chemistry; Permeability (electromagnetism); Pharmacology; Intestinal permeability; Medicine; Botany; Biochemistry; Biology; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004577911,0.0001569305,0.0003525024,0.00007833831,0.00007214428,0.0000103593,0.00008382487,0.00008918649,0.00003209361],"category_scores_gemma":[0.000008750042,0.00014312,0.0001137875,0.00005594271,0.0001313159,0.00001613949,0.00006357391,0.0002148364,1.935825e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001671522,"about_ca_system_score_gemma":0.00006102458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000563787,"about_ca_topic_score_gemma":0.00000716341,"domain_scores_codex":[0.9987983,0.0001794931,0.0004929987,0.0002065471,0.0001176132,0.0002050797],"domain_scores_gemma":[0.9992795,0.00007220787,0.0003868871,0.00007135139,0.0000904129,0.00009962847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003499467,0.0003191039,0.003639334,0.0001828062,0.00008821883,0.00002760085,0.0001627292,0.0001368453,0.9906173,0.000001350382,0.0002777892,0.001047481],"study_design_scores_gemma":[0.005611346,0.001030784,0.006063543,0.000006376127,0.0001549056,0.0001343197,0.00009335559,0.0002581581,0.9849481,0.00001585011,0.001569455,0.0001138066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970838,0.00204466,0.00002599352,0.0001739313,0.0002445627,0.0002309598,0.0001151945,0.000001304625,0.0000796091],"genre_scores_gemma":[0.9987984,0.0007411036,0.00003235439,0.0001941076,0.00017284,0.000004948033,0.00001016899,0.00001069749,0.00003532149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005669174,"threshold_uncertainty_score":0.5836265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009844694039631237,"score_gpt":0.332737820137849,"score_spread":0.3228931260982177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}