{"id":"W2163512218","doi":"10.1128/aac.00380-06","title":"Mutations in the E9L Polymerase Gene of Cidofovir-Resistant Vaccinia Virus Strain WR Are Associated with the Drug Resistance Phenotype","year":2006,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Eye Institute","keywords":"Virology; Biology; Vaccinia; Virus; Orthopoxvirus; Cidofovir; Poxviridae; Serial passage; Polymerase; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398302,0.0003958658,0.0002770503,0.0002445276,0.0001416951,0.0002722862,0.0001904284,0.0003511956,0.001333986],"category_scores_gemma":[0.0002242908,0.0002072126,0.0003383823,0.0001166104,0.0002680401,0.0001304481,0.0001919652,0.0006202201,0.000791107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003553561,"about_ca_system_score_gemma":0.0001745678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004435384,"about_ca_topic_score_gemma":0.000406402,"domain_scores_codex":[0.9998122,0.000026822,0.00002831258,0.00005314805,0.00004522366,0.00003430769],"domain_scores_gemma":[0.9998077,0.00004173131,0.00006706644,0.00002899246,0.00001110388,0.00004347754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004847893,0.00001283474,0.0002243054,0.00001047763,0.000003369167,0.00006840728,0.00000770907,0.00002662186,0.9990166,0.00004164707,0.0000123739,0.0005271217],"study_design_scores_gemma":[0.00001864722,0.0002057901,0.005552126,0.00000692571,0.00001242674,0.0009771727,0.00001717517,0.0007247541,0.9896514,0.000032905,0.00279294,0.000007784483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942982,0.000357288,0.003785585,0.00004261985,0.00003646672,0.00004356806,0.0004602749,0.00007932906,0.0008967293],"genre_scores_gemma":[0.9922924,0.0002143423,0.003849067,0.0000302697,0.000007701467,0.00002436712,0.001024902,0.00005182593,0.002505178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333986,"threshold_uncertainty_score":0.0044626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008619408070630321,"score_gpt":0.2377174655446695,"score_spread":0.2290980574740392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}