{"id":"W2163546813","doi":"10.1371/journal.pgen.1004679","title":"Break-Induced Replication Requires DNA Damage-Induced Phosphorylation of Pif1 and Leads to Telomere Lengthening","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Medical Research Council; Darwin Trust of Edinburgh; Wellcome Trust","keywords":"Biology; Telomere; Telomerase; RAD51; Replication protein A; DNA damage; G2-M DNA damage checkpoint; DNA replication; Homologous recombination; Cell biology; DNA repair; Control of chromosome duplication; RAD52; Telomere-binding protein; Replication factor C; Molecular biology; DNA ligase; DNA; Genetics; Cell cycle; Cell cycle checkpoint; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081496,0.000401737,0.0002221853,0.0002300768,0.0001832654,0.0003025857,0.0003293552,0.0003558574,0.001808165],"category_scores_gemma":[0.0001243394,0.0002892276,0.0002990299,0.0001632986,0.0002294608,0.0002712115,0.0003962982,0.0006870214,0.00064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240205,"about_ca_system_score_gemma":0.000197157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006653386,"about_ca_topic_score_gemma":0.0008485962,"domain_scores_codex":[0.9998786,0.000009694902,0.00001393003,0.00003570191,0.00002968539,0.00003226061],"domain_scores_gemma":[0.9998679,0.00001467173,0.00003983124,0.00002379206,0.000007234899,0.0000464826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005798,0.00001770068,0.0001424063,0.00001957961,0.000003032385,0.00007734275,0.000004002622,0.00006086179,0.9989177,0.00007280411,0.00002028931,0.0005636687],"study_design_scores_gemma":[0.00001798303,0.0001359423,0.006756512,0.000004587962,0.000007802794,0.0005200087,0.00001383822,0.0008947795,0.9902948,0.00008762193,0.00125984,0.000006325599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957454,0.001116849,0.001638766,0.00007223173,0.00003095794,0.00001442966,0.0004335719,0.00009670515,0.0008511372],"genre_scores_gemma":[0.9961677,0.0003652433,0.001067821,0.00002182462,0.00000600527,0.00001602623,0.0007304556,0.00002601564,0.001598839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808165,"threshold_uncertainty_score":0.006048918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122192130249978,"score_gpt":0.2596278860123435,"score_spread":0.2384059647098438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}