{"id":"W2163546813","doi":"10.1371/journal.pgen.1004679","title":"Break-Induced Replication Requires DNA Damage-Induced Phosphorylation of Pif1 and Leads to Telomere Lengthening","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Medical Research Council; Darwin Trust of Edinburgh; Wellcome Trust","keywords":"Biology; Telomere; Telomerase; RAD51; Replication protein A; DNA damage; G2-M DNA damage checkpoint; DNA replication; Homologous recombination; Cell biology; DNA repair; Control of chromosome duplication; RAD52; Telomere-binding protein; Replication factor C; Molecular biology; DNA ligase; DNA; Genetics; Cell cycle; Cell cycle checkpoint; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000246792,0.0001626832,0.0001744921,0.00006030317,0.00006288364,0.00001961279,0.0001837349,0.000176753,0.000007689162],"category_scores_gemma":[0.0003684405,0.000174499,0.00004338647,0.0001103393,0.00002671283,0.000004719431,0.0001544665,0.00006516517,0.000007706019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001339566,"about_ca_system_score_gemma":0.00003965674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005450986,"about_ca_topic_score_gemma":0.00001340882,"domain_scores_codex":[0.9987699,0.00007162953,0.0002856596,0.000487987,0.0001828107,0.0002020602],"domain_scores_gemma":[0.9987327,0.00002065066,0.0001454557,0.0008233237,0.0001497624,0.000128043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003213031,0.00004060111,0.0008526743,0.00002979261,0.00002406159,2.123438e-7,0.0001417164,0.00003142242,0.989589,0.0001982396,0.00005211352,0.009008015],"study_design_scores_gemma":[0.0002677022,0.000624634,0.002227496,0.00002791681,0.0000357086,0.000003752376,0.00004233999,0.001733779,0.9940299,0.0001907373,0.0006199254,0.0001960721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979082,0.0001175355,0.0006852,0.000124808,0.000070362,0.0002990151,0.000005749487,0.00002842897,0.000760737],"genre_scores_gemma":[0.9954931,0.00003112618,0.003962922,0.000166125,0.0001372956,0.00002717458,0.00003786128,0.00004174767,0.0001027209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008811943,"threshold_uncertainty_score":0.7115861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122192130249978,"score_gpt":0.2596278860123435,"score_spread":0.2384059647098438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}