{"id":"W2163560954","doi":"10.1101/gad.244848.114","title":"<i>Setdb1</i> is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministry of Education, Culture, Sports, Science and Technology; Michael Smith Health Research BC; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre","keywords":"Biology; Germline; Endogenous retrovirus; Retrotransposon; DNA methylation; Epigenetics; Genetics; Chromatin; Histone; Chromatin immunoprecipitation; Methylation; Molecular biology; Gene; Genome; Transposable element; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002081364,0.0004692651,0.0004005922,0.0003540951,0.0003964975,0.0008158486,0.0007629847,0.000433677,0.003361904],"category_scores_gemma":[0.0002464797,0.0003815561,0.0004965499,0.0002266837,0.0004630655,0.0002197729,0.0007635149,0.0009581932,0.002257281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006431334,"about_ca_system_score_gemma":0.0003434943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001568225,"about_ca_topic_score_gemma":0.002567349,"domain_scores_codex":[0.9996363,0.00003644987,0.00004898789,0.0001063822,0.0001119278,0.00006002597],"domain_scores_gemma":[0.9994449,0.00006919902,0.0001915201,0.00005418166,0.00003197523,0.0002083264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005632388,0.00001387983,0.0004541239,0.00003198894,0.000006778103,0.00008097097,0.00001262723,0.00005278442,0.9983861,0.0001087924,0.00009591957,0.000699708],"study_design_scores_gemma":[0.00002474819,0.00006515146,0.03970123,0.00002377862,0.00002224199,0.0005633291,0.00005628858,0.002326793,0.9516929,0.00008048715,0.005427994,0.00001514117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981808,0.001972219,0.007792864,0.0002175948,0.00008724771,0.00003501515,0.004391957,0.0005742276,0.003120939],"genre_scores_gemma":[0.9892841,0.0003421981,0.002079992,0.0001517424,0.00001189937,0.00003745367,0.00412306,0.0002372503,0.003732157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003361904,"threshold_uncertainty_score":0.01124674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03155392538415268,"score_gpt":0.213321686020659,"score_spread":0.1817677606365063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}