{"id":"W2163560954","doi":"10.1101/gad.244848.114","title":"<i>Setdb1</i> is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministry of Education, Culture, Sports, Science and Technology; Michael Smith Health Research BC; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre","keywords":"Biology; Germline; Endogenous retrovirus; Retrotransposon; DNA methylation; Epigenetics; Genetics; Chromatin; Histone; Chromatin immunoprecipitation; Methylation; Molecular biology; Gene; Genome; Transposable element; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000408929,0.0001838905,0.0002784588,0.00002865596,0.0001944237,0.00002529943,0.0001689551,0.00008977259,0.00007239415],"category_scores_gemma":[0.00003825695,0.0000926297,0.00004897661,0.0001944415,0.00003549517,0.00004555799,0.0001180269,0.00004347546,0.000008226473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005154606,"about_ca_system_score_gemma":0.00008995069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006220709,"about_ca_topic_score_gemma":0.0007002463,"domain_scores_codex":[0.9985,0.0000422686,0.0005440192,0.0003697599,0.0002081427,0.0003358137],"domain_scores_gemma":[0.9994009,0.0002023561,0.0001559439,0.00006516388,0.00008331152,0.00009237736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003462068,0.00007186549,0.004944939,0.00003106561,0.00001808891,7.877184e-7,0.001304368,0.00000753516,0.6868712,0.00002955974,0.00003790797,0.3066481],"study_design_scores_gemma":[0.0004669214,0.0001215338,0.1148444,0.00004494203,0.00001144402,0.000004549469,0.0001300012,0.00005146377,0.8263327,0.0002468578,0.05745349,0.0002916614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985622,0.0003368852,0.00008797974,0.0001845704,0.0001460324,0.0004158956,0.00002669584,0.00002344242,0.0002162856],"genre_scores_gemma":[0.9848064,0.0000882088,0.01447488,0.0002459932,0.0001129383,0.00009206964,0.00005648792,0.000002420225,0.000120588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3063564,"threshold_uncertainty_score":0.377733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03155392538415268,"score_gpt":0.213321686020659,"score_spread":0.1817677606365063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}