{"id":"W2163579392","doi":"10.1126/science.287.5455.1040","title":"Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration","year":2000,"lang":"en","type":"article","venue":"Science","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1025,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Amgen (Canada); Ontario Institute for Cancer Research","funders":"","keywords":"Heterotrimeric G protein; Cell biology; Chemotaxis; Thymocyte; Kinase; Biology; Protein kinase B; Signal transduction; Chemistry; G protein; T cell; Receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009810642,0.0003903746,0.00008451443,0.0002408531,0.0002428107,0.0003175887,0.000195791,0.00024934,0.0005253459],"category_scores_gemma":[0.00009590513,0.0001143194,0.0001154935,0.0001065262,0.0003281344,0.0001845819,0.0002219071,0.00048054,0.0002306158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005758382,"about_ca_system_score_gemma":0.0003297875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007119539,"about_ca_topic_score_gemma":0.0009064759,"domain_scores_codex":[0.9999408,0.00000780808,0.000004024111,0.00001545441,0.00001573138,0.00001614504],"domain_scores_gemma":[0.9999431,0.000003836307,0.00001775723,0.000005636301,0.000004950253,0.00002465594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000218416,0.00001667036,0.0005743644,0.0000287097,0.000004278405,0.0001753968,0.00001678378,0.0000843044,0.9938019,0.0009455095,0.0000671681,0.00406652],"study_design_scores_gemma":[0.0000556662,0.0001883596,0.01426083,0.00002252583,0.0000306282,0.00127912,0.00005573494,0.000947545,0.9738897,0.001151986,0.008110237,0.000007766697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715016,0.01445435,0.006367296,0.0005132008,0.00004934347,0.00002594694,0.0003922395,0.0001242142,0.006571837],"genre_scores_gemma":[0.9927245,0.003607148,0.001236026,0.00005289896,0.000008170612,0.00001673204,0.0001689742,0.00000902199,0.002176662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007119539,"threshold_uncertainty_score":0.004178047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006681642254075763,"score_gpt":0.2057281638982784,"score_spread":0.1990465216442027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}