{"id":"W2163579392","doi":"10.1126/science.287.5455.1040","title":"Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration","year":2000,"lang":"en","type":"article","venue":"Science","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1025,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Amgen (Canada); Ontario Institute for Cancer Research","funders":"","keywords":"Heterotrimeric G protein; Cell biology; Chemotaxis; Thymocyte; Kinase; Biology; Protein kinase B; Signal transduction; Chemistry; G protein; T cell; Receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001811643,0.00004176231,0.00003547181,0.00004455793,0.00005166459,0.00001008376,0.0000718341,0.00002786012,0.00001298269],"category_scores_gemma":[0.00001552662,0.0000402208,0.000006476967,0.0001844173,0.0001010438,0.000009443107,0.00001793928,0.00002337396,0.000003026177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009479068,"about_ca_system_score_gemma":0.0001154592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001093787,"about_ca_topic_score_gemma":0.00002417282,"domain_scores_codex":[0.9995405,0.000009920743,0.00009197125,0.0001756277,0.00009288771,0.00008909957],"domain_scores_gemma":[0.9998133,0.000002805592,0.00003033921,0.00009160768,0.0000395665,0.00002237159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001858441,0.00001413499,0.003203635,0.000003822146,4.737639e-7,8.73258e-8,0.00009381335,0.0001253639,0.9896274,0.000008980522,0.00001117146,0.006892573],"study_design_scores_gemma":[0.0001291166,0.00005579723,0.07016343,0.000005900414,7.375492e-7,6.656517e-7,0.00001723095,0.00005286511,0.9263143,0.00003913883,0.00317587,0.00004498179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985431,0.00007485529,0.0005822906,0.00002616629,0.00002474481,0.00004853531,5.321985e-7,0.000002952116,0.0006968686],"genre_scores_gemma":[0.998963,0.0000277959,0.0006652516,0.00005487108,0.00001617848,0.000003176718,0.000005982037,0.000002499858,0.0002612746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06695979,"threshold_uncertainty_score":0.1640157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006681642254075763,"score_gpt":0.2057281638982784,"score_spread":0.1990465216442027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}