{"id":"W2163623676","doi":"10.1084/jem.20120790","title":"Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain","year":2012,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"National Institute of Allergy and Infectious Diseases","keywords":"T-cell receptor; Cytoplasm; CD3; Cell biology; Lipid bilayer; SH3 domain; Biology; Biophysics; Cell membrane; Membrane; Chemistry; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Biochemistry; T cell; CD8; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004745203,0.0001216322,0.0001467777,0.0001026082,0.0001488612,0.0003074507,0.0001130752,0.0001830799,0.0007769313],"category_scores_gemma":[0.00009883696,0.00009976379,0.00009989449,0.00008715648,0.0002389895,0.0002185521,0.0002199687,0.0003155121,0.0002257101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003312388,"about_ca_system_score_gemma":0.0001007951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003468044,"about_ca_topic_score_gemma":0.0004993937,"domain_scores_codex":[0.99993,0.00000617077,0.000003387451,0.00001383261,0.00001642936,0.00003019252],"domain_scores_gemma":[0.9999462,0.000008472761,0.00001665619,0.000003788393,0.000006989498,0.00001781304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008455124,0.000006112495,0.0002277538,0.000007897132,0.000001427381,0.00004005342,0.00001296479,0.00002535444,0.9991469,0.00003339542,0.00001057393,0.0004028916],"study_design_scores_gemma":[0.00002600583,0.00009348997,0.0252196,0.00000443789,0.00001264412,0.000269937,0.0001212678,0.001218044,0.9722534,0.000107331,0.0006680656,0.000005930296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985681,0.0003952932,0.0005074118,0.00002482671,0.000004122871,0.000003919582,0.00004793201,0.00001646881,0.0004319051],"genre_scores_gemma":[0.9991075,0.0002068515,0.0002590101,0.00001602701,0.000002575357,0.000006688331,0.00005733704,0.000005901936,0.0003379566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007769313,"threshold_uncertainty_score":0.002599061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130637037551151,"score_gpt":0.2305104307262712,"score_spread":0.2192040603507596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}