{"id":"W2163667875","doi":"10.4161/cc.6.15.4516","title":"The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence","year":2007,"lang":"en","type":"review","venue":"Cell Cycle","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"DNA damage; Senescence; Biology; Carcinogenesis; Cell biology; Cell cycle; Cell cycle checkpoint; DNA repair; Genome instability; Cell; Cell growth; Signal transduction; DNA; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008275305,0.0007382712,0.001675717,0.0002455659,0.000428172,0.0001142052,0.0007623918,0.0004593001,0.0001344202],"category_scores_gemma":[0.0001982254,0.0005109399,0.0006705067,0.0008215811,0.0001673446,0.00006158334,0.000212049,0.0008665115,0.0008951463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374409,"about_ca_system_score_gemma":0.0006713725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005597727,"about_ca_topic_score_gemma":0.00002977074,"domain_scores_codex":[0.9961423,0.0002346612,0.0009747963,0.0009172866,0.0007011901,0.001029755],"domain_scores_gemma":[0.9966806,0.0008849631,0.0003868057,0.001206466,0.0001689295,0.0006722929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004677634,0.000235456,0.00002024961,0.01481154,0.0001284596,0.00130712,0.000427516,0.000005361519,0.01143832,0.00006753297,0.0007554102,0.9707562],"study_design_scores_gemma":[0.0003367662,0.0001444462,0.000007664371,0.008698654,0.0004878888,0.0000487971,0.000226665,0.00001219473,0.02919878,0.00000909192,0.9602163,0.0006126984],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003991867,0.9902322,0.0003287893,0.00004966422,0.0007147999,0.001677645,0.00006824683,0.0001631072,0.002773628],"genre_scores_gemma":[0.007289712,0.9870113,0.0002718527,0.0003277704,0.0009846695,0.00006828521,0.000146639,0.0001798935,0.003719854],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9701436,"threshold_uncertainty_score":0.9998828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04403953135013387,"score_gpt":0.3177157836380191,"score_spread":0.2736762522878852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}